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Prognostic relevance of the Ki-67 proliferation index in patients with mantle cell lymphoma
- Prognostic relevance of the Ki-67 proliferation index in patients with mantle cell lymphoma
- Jeong T.-D.; Chi H.-S.; Kim M.-S.; Jang S.; Park C.-J.; Huh J.R.
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- Blood Research
- vol. 51, no. 2, pp. 127 - 132
- Bone marrow; Ki-67 proliferation index; Mantle cell lymphoma; Prognosis
- Korean Society of Hematology
- SCOPUS; KCI
- Background A high Ki-67 proliferation index (PI) in neoplastic cells is associated with poor survival in mantle cell lymphoma (MCL). We aimed to determine the cut-off values for the Ki-67 PI as a prognostic factor in MCL according to bone marrow findings. Methods Immunohistochemical (IHC) staining for Ki-67 was performed on formalin-fixed paraffin- embedded biopsy tissues from 56 patients with MCL. Patients were grouped based on their Ki-67 PI values. Survival analyses were carried out and the cut-off value for the Ki-67 PI was determined. Results Of the 56 patients, 39 (69.6%) showed bone marrow involvement of MCL; 21 of these patients had leukemic manifestations at the time of diagnosis. The results of the Ki-67 IHC staining were as follows: ≤10% in 22 patients, 11-20% in 14 patients, 21-30% in 3 patients, 31-40% in 4 patients, 41-50% in 4 patients, and >50% in 9 patients. A cut-off value of 20% revealed significantly different survival rates with mean survival times of 69.8 months (Ki-67 PI≤20%) and 47.9 months (Ki-67 PI>20%), irrespective of bone marrow findings (P=0.034). Clinical outcomes did not differ, regardless of bone marrow findings. However, in cases with bone marrow involvement, the Ki-67 cut-off value of 30% for overall survival was required to yield statistical significance (P=0.033). Conclusion The 20% cut-off value for the Ki-67 PI was clinically meaningful, regardless of bone marrow involvement of MCL. For patients with bone marrow involvement, the statistically significant cut-off value increased to 30%. © 2016 Korean Society of Hematology.
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