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dc.contributor.author박혜영-
dc.date.accessioned2016-12-28T02:12:40Z-
dc.date.available2016-12-28T02:12:40Z-
dc.date.issued2016-
dc.identifier.issn0006-291X-
dc.identifier.issn1090-2104-
dc.identifier.otherOAK-19680-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/233364-
dc.description.abstract5-Lipoxygenase (5-LOX) is an enzyme that converts arachidonic acid from the cell membrane into leukotriene, a signal lipid mediator. 5-LOX deficiency markedly attenuates the formation of aneurysms in knockout mice. In addition, Zileuton, a clinical drug targeting 5-LOX, is used for treatment of asthma. However, it is unclear whether 5-LOX inhibition results in anti-angiogenic effects for applications in cancer therapy. To explore the roles of 5-LOX in angiogenesis and its potential as a therapeutic target in cancer, the effects of a newly synthesized 5-LOX inhibitor, F3, on in vitro and in vivo angiogenesis were investigated. The results showed that 5-LOX inhibition by F3 suppressed in vitro vascular endothelial growth factor (VEGF)-induced tube formation and chemo-invasion of endothelial cells (ECs). 5-LOX inhibition also decreased VEGF-induced extracellular signal-regulated kinase (ERK) phosphorylation in ECs. Notably, 5-LOX knockdown phenocopied the anti-angiogenic activity of the 5-LOX inhibitor F3 in a concentration-dependent manner. F3 did not affect the activities of VEGF receptor 2 or AKT. In vivo, the compound significantly inhibited the formation of the chorioallantoic membrane at nontoxic doses. These results demonstrated that 5-LOX played an important role in angiogenesis and that its inhibitor F3 could be a new anti-angiogenic agent targeting VEGF signaling.-
dc.languageEnglish-
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE-
dc.subject5-Lipoxygenase-
dc.subjectAnti-angiogenic effects-
dc.subjectVascular endothelial growth factor signaling-
dc.titleInhibition of 5-lipoxygenase suppresses vascular endothelial growth factor-induced angiogenesis in endothelial cells-
dc.typeArticle-
dc.relation.issue3-
dc.relation.volume478-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage1117-
dc.relation.lastpage1122-
dc.relation.journaltitleBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.identifier.doi10.1016/j.bbrc.2016.08.078-
dc.identifier.wosidWOS:000397715400016-
dc.identifier.scopusid2-s2.0-84993958529-
dc.author.googleKim, Tae Young-
dc.author.googleKim, Joohye-
dc.author.googleChoo, Hea-Young Park-
dc.author.googleKwon, Ho Jeong-
dc.contributor.scopusid박혜영(34972649500;57200273796)-
dc.date.modifydate20230411110509-
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약학대학 > 약학과 > Journal papers
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