View : 103 Download: 0

The 99th percentile values of six cardiac troponin assays established for a reference population using strict selection criteria

Title
The 99th percentile values of six cardiac troponin assays established for a reference population using strict selection criteria
Authors
Ko, Dae-HyunJeong, Tae-DongCho, Eun-JungLim, JinsookJi, MisukLee, KyunghoonLee, WoochangYun, Yeo-MinChun, SailSong, JunghanKwon, Kye-ChulMin, Won-Ki
Ewha Authors
정태동
SCOPUS Author ID
정태동scopus
Issue Date
2017
Journal Title
CLINICA CHIMICA ACTA
ISSN
0009-8981JCR Link1873-3492JCR Link
Citation
vol. 464, pp. 1 - 5
Keywords
Troponin99th percentileReference populationSouth Korean
Publisher
ELSEVIER SCIENCE BV
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Background: Since the 99th percentile reference limit for cardiac troponin (Tn) can vary depending on the reference population, Sandoval et al. published systematic selection criteria. In this study, these systematic criteria were applied for the first time to obtain the 99th percentile reference limits for 6 Tn tests. Methods: The reference population was selected in accordance with the systematic criteria, and reference limits were set with respect to the six types of Tn assays. The coefficient of variation (CV) at the reference limit was determined using 3-4 concentrations of frozen serum. Results: In total, 641 South Koreans (303 males, 338 females) were selected as the reference population. The 99th percentile reference limit of Tn in the six assays ranged from 13.4 to 34.2 pg/mI. The measurable fractions among the reference population ranged from 13% to 80.5%. The CVs at the reference limit ranged from 5.3% to 43.0%, and three were <10%. Conclusions: In this study, a reference population was selected for the first time in accordance with the systematic criteria of Sandoval et al., and the reference limit for South Koreans was established. The values obtained in this study are different from those proposed by manufacturers, which confirms the importance of having a reference population. Four out of six assays did not fulfill the criteria for high-sensitivity tests. (C) 2016 Elsevier B.V. All rights reserved.
DOI
10.1016/j.cca.2016.11.004
Appears in Collections:
의료원 > 의료원 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE