Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 안영호 | * |
dc.date.accessioned | 2016-12-28T02:12:34Z | - |
dc.date.available | 2016-12-28T02:12:34Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 2162-4011 | * |
dc.identifier.other | OAK-19732 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/233330 | - |
dc.description.abstract | Cancer cells modulate the recruitment and function of inflammatory cells to create an immunosuppressive microenvironment that favors tumor growth and metastasis. However, the tumor-derived regulatory programs that promote intratumoral immunosuppression remain poorly defined. Here, we show in a KrasLA1/+p53R172HΔg/+-based mouse model that bone morphogenetic protein-4 (BMP4) augments the expression of the T cell co-inhibitory receptor ligand PD-L1 in the mesenchymal subset of lung cancer cells, leading to profound CD8+ T cell-mediated immunosuppression, producing tumor growth and metastasis. We previously reported in this model that BMP4 functions as a pro-tumorigenic factor regulated by miR-200 via GATA4/6. Thus, BMP4‐mediated immunosuppression is part of a larger miR‐200‐directed gene expression program in tumors that promotes tumor progression, which could have important implications for cancer treatment. © 2016 Taylor & Francis Group, LLC. | * |
dc.language | English | * |
dc.publisher | Taylor and Francis Inc. | * |
dc.subject | BMP4 | * |
dc.subject | EMT | * |
dc.subject | immunotherapy | * |
dc.subject | lung cancer | * |
dc.subject | miR-200 | * |
dc.subject | PD-L1 | * |
dc.title | Growth and metastasis of lung adenocarcinoma is potentiated by BMP4-mediated immunosuppression | * |
dc.type | Article | * |
dc.relation.issue | 11 | * |
dc.relation.volume | 5 | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | OncoImmunology | * |
dc.identifier.doi | 10.1080/2162402X.2016.1234570 | * |
dc.identifier.wosid | WOS:000389145800021 | * |
dc.identifier.scopusid | 2-s2.0-84994662297 | * |
dc.author.google | Chen L. | * |
dc.author.google | Yi X. | * |
dc.author.google | Goswami S. | * |
dc.author.google | Ahn Y.-H. | * |
dc.author.google | Roybal J.D. | * |
dc.author.google | Yang Y. | * |
dc.author.google | Diao L. | * |
dc.author.google | Peng D. | * |
dc.author.google | Fradette J.J. | * |
dc.author.google | Wang J. | * |
dc.author.google | Byers L.A. | * |
dc.author.google | Kurie J.M. | * |
dc.author.google | Ullrich S.E. | * |
dc.author.google | Qin F.X.-F. | * |
dc.author.google | Gibbons D.L. | * |
dc.contributor.scopusid | 안영호(7202402440) | * |
dc.date.modifydate | 20240222132209 | * |