View : 20 Download: 0

Growth and metastasis of lung adenocarcinoma is potentiated by BMP4-mediated immunosuppression

Title
Growth and metastasis of lung adenocarcinoma is potentiated by BMP4-mediated immunosuppression
Authors
Chen L.Yi X.Goswami S.Ahn Y.-H.Roybal J.D.Yang Y.Diao L.Peng D.Fradette J.J.Wang J.Byers L.A.Kurie J.M.Ullrich S.E.Qin F.X.-F.Gibbons D.L.
Ewha Authors
안영호
SCOPUS Author ID
안영호scopus
Issue Date
2016
Journal Title
OncoImmunology
ISSN
2162-4011JCR Link
Citation
vol. 5, no. 11
Keywords
BMP4EMTimmunotherapylung cancermiR-200PD-L1
Publisher
Taylor and Francis Inc.
Indexed
SCOPUS WOS scopus
Abstract
Cancer cells modulate the recruitment and function of inflammatory cells to create an immunosuppressive microenvironment that favors tumor growth and metastasis. However, the tumor-derived regulatory programs that promote intratumoral immunosuppression remain poorly defined. Here, we show in a KrasLA1/+p53R172HΔg/+-based mouse model that bone morphogenetic protein-4 (BMP4) augments the expression of the T cell co-inhibitory receptor ligand PD-L1 in the mesenchymal subset of lung cancer cells, leading to profound CD8+ T cell-mediated immunosuppression, producing tumor growth and metastasis. We previously reported in this model that BMP4 functions as a pro-tumorigenic factor regulated by miR-200 via GATA4/6. Thus, BMP4‐mediated immunosuppression is part of a larger miR‐200‐directed gene expression program in tumors that promotes tumor progression, which could have important implications for cancer treatment. © 2016 Taylor & Francis Group, LLC.
DOI
10.1080/2162402X.2016.1234570
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE