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Reversal of an unconditioned behavioral preference for specific food pellets by intervention of whisker sensory inputs

Title
Reversal of an unconditioned behavioral preference for specific food pellets by intervention of whisker sensory inputs
Authors
Kim H.Lee Y.Kim J.-E.Han P.-L.
Ewha Authors
한평림김지은
SCOPUS Author ID
한평림scopus; 김지은scopus
Issue Date
2016
Journal Title
Experimental Neurobiology
ISSN
1226-2560JCR Link
Citation
Experimental Neurobiology vol. 25, no. 2, pp. 79 - 85
Keywords
Dorsal striatumUnconditioned preferenceWhisker-trimming
Publisher
Korean Society for Neurodegenerative Disease
Indexed
SCOPUS; KCI scopus
Document Type
Article
Abstract
Adenylyl cyclase type-5 (AC5) is preferentially expressed in the dorsal striatum. Recently, we reported that AC5 knockout (KO) mice preferred food pellets carrying an olfactory cue produced by AC5 KO mice during food consumption (AC5 KO pellets) over food pellets that had been taken by wildtype (WT) mice. In the present study, we demonstrated that whisker trimming on the right side of the face but not the left in AC5 KO mice blocked the behavioral preference for AC5 KO pellets. Conversely, whisker trimming on the right but not the left in WT mice induced a behavioral preference for AC5 KO pellets. Mice lacking D2 dopamine receptor (D2 KO mice) also showed a behavioral preference for AC5 KO pellets. In D2 mice, whisker trimming on the right side of the face but not the left blocked a behavioral preference for AC5 KO food pellets. AC5 KO mice had increased level of phospho-CaMKIIa in the dorsal striatum, and WT mice with whiskers cut on either side also showed increased p-CaMKIIa level in the dorsal striatum. The siRNAmediated inhibition of CaMKIIa in the dorsal striatum in either the right or the left hemisphere in AC5 KO mice and D2 KO mice blocked the behavioral preference for AC5 KO pellets. However, behavioral changes induced by this inhibition on each side showed asymmetrical time courses. These results suggest that an unconditioned behavioral preference for specific food pellets can be switched on or off based on the balance of states of neural activity in the dorsal striatum regulated by a signaling pathway centered on AC5 and D2 and the sensory inputs of whiskers from the right side of the face. © Experimental Neurobiology 2016.
DOI
10.5607/en.2016.25.2.79
Appears in Collections:
일반대학원 > 뇌·인지과학과 > Journal papers
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