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Accelerated whole breast irradiation in early breast cancer patients with adverse prognostic features

Title
Accelerated whole breast irradiation in early breast cancer patients with adverse prognostic features
Authors
Lee, Sea-WonShin, Kyung HwanChie, Eui KyuKim, Jin HoIm, Seock-AhHan, WonshikNoh, Dong-YoungLim, Hyeon WooKim, Tae HyunLee, Keun SeokLee, Eun SookSung, Soo YoonKim, Kyubo
Ewha Authors
김규보
SCOPUS Author ID
김규보scopusscopus
Issue Date
2016
Journal Title
ONCOTARGET
ISSN
1949-2553JCR Link
Citation
vol. 7, no. 49, pp. 81888 - 81898
Keywords
early breast cancerrisk factorhypofractionation
Publisher
IMPACT JOURNALS LLC
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Purpose: Accelerated whole breast irradiation (AWBI) and conventional whole breast irradiation (CWBI) were compared to determine whether AWBI is as effective as CWBI in patients with early breast cancer and adverse prognostic features. Patients and methods: We included 330 patients who underwent breast-conserving surgery (BCS) and post-operative radiation therapy (RT) using AWBI for pT1-2 and pN0-1a breast cancer from 2007 to 2010. These patients were matched with 330 patients who received CWBI according to stage, age (+/- 3 years), and the year of BCS. AWBI of 39 Gy and CWBI of 50.4 Gy were given in 13 and 28 fractions, respectively. Results: Median follow-up time was 81.9 months. There were no statistically significant differences between the AWBI and CWBI groups in terms of age, stage, tumor grade, or molecular subtype. More patients with Ki-67 index >= 14% were present in the AWBI group (AWBI 47.0% vs. CWBI 10.3%; P<0.01). The 5-year ipsilateral breast tumor relapse (IBTR) rates for the AWBI and CWBI groups were 0.8% and 1.8%, respectively (P=0.54). High tumor grade was a statistically significant risk factor for IBTR (5-year IBTR rate: 2.9%; P=0.01). Ki-67 >= 14% was marginally related to IBTR (5-year IBTR rate: 2.2%; P=0.07). There were no statistically significant differences in the hazard ratios between the AWBI and CWBI groups according to any of the risk factors. There were no acute grade 3 toxicities in the AWBI group. There were no late grade 3 toxicities in either group. Conclusions: AWBI is comparable to CWBI in early breast cancer with adverse prognostic features.
DOI
10.18632/oncotarget.11702
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의학전문대학원 > 의학과 > Journal papers
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