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Cross-protection against Vibrio cholerae infection by monoclonal antibodies against Vibrio vulnificus RtxA1/MARTX(Vv)

Title
Cross-protection against Vibrio cholerae infection by monoclonal antibodies against Vibrio vulnificus RtxA1/MARTX(Vv)
Authors
Lee, Tae HeeCha, Sun-ShinLee, Chang-SeopRhee, Joon HaengWoo, Hye RyunChung, Kyung Min
Ewha Authors
차선신
SCOPUS Author ID
차선신scopus
Issue Date
2016
Journal Title
MICROBIOLOGY AND IMMUNOLOGY
ISSN
0385-5600JCR Link1348-0421JCR Link
Citation
vol. 60, no. 11, pp. 793 - 800
Keywords
cross-protectionMARTX toxinmonoclonal antibodyVibrio species
Publisher
WILEY-BLACKWELL
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Gram-negative Vibrio species secrete multifunctional autoprocessing repeats-in-toxin (MARTX) toxins associated with bacterial pathogenesis. Here, the cross-reactivity and cross-protectivity of mAbs against V. vulnificus RtxA1/MARTX(Vv) was evaluated. Passive administration of any of these mAbs (21RA, 24RA, 46RA, 47RA and 50RA) provided strong protection against lethal V. cholerae infection. Interestingly, 24RA and 46RA, which map to the cysteine protease domain of V. cholerae MARTX(Vc), inhibited CPD autocleavage in vitro; this process is involved in V. cholerae pathogenesis. These results generate new insight into the development of broadly protective mAbs and/or vaccines against Vibrio species with MARTX toxins.
DOI
10.1111/1348-0421.12449
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자연과학대학 > 화학·나노과학전공 > Journal papers
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