View : 260 Download: 0

Full metadata record

DC Field Value Language
dc.contributor.author김규보-
dc.date.accessioned2016-12-28T02:12:25Z-
dc.date.available2016-12-28T02:12:25Z-
dc.date.issued2016-
dc.identifier.issn0179-1958-
dc.identifier.issn1432-1262-
dc.identifier.otherOAK-19165-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/233277-
dc.description.abstractWe evaluate whether the change of carcinoembryonic antigen (CEA) level before and after preoperative chemoradiotherapy (CRT) in rectal cancer affects tumor response and recurrence or not. We retrospectively analyzed 1447 rectal cancer patients who underwent preoperative CRT followed by curative surgery. All patients received preoperative radiotherapy of 50.4 Gy in 28 fractions with 5-fluorouracil or capecitabine. Total mesorectal excision was performed 4 to 8 weeks after preoperative CRT. CEA levels were checked before and after CRT. Clinical and pathologic factors were analyzed for tumor response and recurrence. Post-CRT CEA level (cutoff value, 2.5 ng/mL) was not a significant factor for tumor response on the multivariate analysis (p = 0.095). Patients were categorized according to the pre- and post-CRT CEA level (group A: pre-CRT CEA aecurrency sign5 ng/mL; group B: pre-CRT CEA > 5 ng/mL and post-CRT CEA aecurrency sign2.5 ng/mL; group C: pre-CRT CEA > 5 ng/mL and post-CRT CEA > 2.5 ng/mL). The relapse-free survival (RFS) at 5 years was significantly higher in group A than in groups B and C (82.6 vs. 73.7 % vs. 72.2 %, p < 0.001). The overall survival (OS) at 5 years was significantly higher in group A than in groups B and C (90.1 vs. 84.4 % vs. 83.4 %, p < 0.001). However, there is no significant difference for RFS and OS between groups B and C (all, p > 0.05). Decline of elevated CEA level (> 5 ng/mL) during preoperative chemoradiotherapy has no significant effect on tumor response and recurrence in rectal cancer.-
dc.languageEnglish-
dc.publisherSPRINGER-
dc.subjectCEA-
dc.subjectChemoradiotherapy-
dc.subjectRectal cancer-
dc.subjectRecurrence-
dc.subjectResponse-
dc.titleCan serum dynamics of carcinoembryonic antigen level during neoadjuvant chemoradiotherapy in rectal cancer predict tumor response and recurrence? A multi-institutional retrospective study-
dc.typeArticle-
dc.relation.issue9-
dc.relation.volume31-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage1595-
dc.relation.lastpage1601-
dc.relation.journaltitleINTERNATIONAL JOURNAL OF COLORECTAL DISEASE-
dc.identifier.doi10.1007/s00384-016-2629-z-
dc.identifier.wosidWOS:000382084300002-
dc.identifier.scopusid2-s2.0-84979984695-
dc.author.googleChung, Mi Joo-
dc.author.googleNam, Taek Keun-
dc.author.googleJeong, Jae Uk-
dc.author.googleKim, Sung Hwan-
dc.author.googleKim, Kyubo-
dc.author.googleJang, Hong Seok-
dc.author.googleJeong, Bae Kwon-
dc.author.googleLee, Jong Hoon-
dc.contributor.scopusid김규보(8213302900)-
dc.date.modifydate20180515132811-
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE