View : 133 Download: 0

Metabolic alterations in the anterior cingulate cortex and related cognitive deficits in late adolescent methamphetamine users

Title
Metabolic alterations in the anterior cingulate cortex and related cognitive deficits in late adolescent methamphetamine users
Authors
Kim J.E.Kim G.H.Hwang J.Kim J.Y.Renshaw P.F.Yurgelun-Todd D.A.Kim B.Kang I.Jeon S.Ma J.Lyoo I.K.Yoon S.
Ewha Authors
김지은류인균윤수정김정윤김건하
SCOPUS Author ID
김지은scopus; 류인균scopus; 윤수정scopus; 김정윤scopus; 김건하scopus
Issue Date
2016
Journal Title
Addiction Biology
ISSN
1355-6215JCR Link
Keywords
AdolescentsAnterior cingulate cortexMagnetic resonance spectroscopyMethamphetamineN-acetyl aspartateStroop interference
Publisher
Blackwell Publishing Ltd
Indexed
SCIE; SCOPUS scopus
Abstract
The adolescent brain, with ongoing prefrontal maturation, may be more vulnerable to drug use-related neurotoxic changes as compared to the adult brain. We investigated whether the use of methamphetamine (MA), a highly addictive psychostimulant, during adolescence affect metabolic and cognitive functions of the anterior cingulate cortex (ACC). In adolescent MA users (n=44) and healthy adolescents (n=53), the levels of N-acetyl aspartate (NAA), a neuronal marker, were examined in the ACC using proton magnetic resonance spectroscopy. The Stroop color-word task was used to assess Stroop interference, which may reflect cognitive functions of behavior monitoring and response selection that are mediated by the ACC. Adolescent MA users had lower NAA levels in the ACC (t=-2.88, P=0.005) and relatively higher interference scores (t=2.03, P=0.045) than healthy adolescents. Moreover, there were significant relationships between lower NAA levels in the ACC and worse interference scores in adolescent MA users (r=-0.61, P<0.001). Interestingly, early onset of MA use, as compared to late onset, was related to both lower NAA levels in the ACC (t=-2.24, P=0.03) as well as lower performance on interference measure of the Stroop color-word task (t=2.25, P=0.03). The current findings suggest that metabolic dysfunction in the ACC and its related cognitive impairment may play an important role in adolescent-onset addiction, particularly during early adolescence. © 2016 Society for the Study of Addiction.
DOI
10.1111/adb.12473
Appears in Collections:
일반대학원 > 뇌·인지과학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE