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Clinical characteristics of parkinsonism in frontotemporal dementia according to subtypes

Title
Clinical characteristics of parkinsonism in frontotemporal dementia according to subtypes
Authors
Park, Hee KyungPark, Kee HyungYoon, BoraLee, Jae -HongChoi, Seong HyeJoung, Jee H.Yoon, Soo JinKim, Byeong C.Kim, Seung HyunKim, Eun-JooNa, Duk L.Park, Kyung Won
Ewha Authors
정지향
SCOPUS Author ID
정지향scopus
Issue Date
2017
Journal Title
JOURNAL OF THE NEUROLOGICAL SCIENCES
ISSN
0022-510XJCR Link1878-5883JCR Link
Citation
vol. 372, pp. 51 - 56
Keywords
ParkinsonismFrontotemporal dementiaPrimary progressive aphasiaMotor neuron disease
Publisher
ELSEVIER SCIENCE BV
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Background: We investigated the prevalence of parkinsonism in frontotemporal dementia (FTD) subtypes and the cognitive and behavioral differences between FTD with and without parkinsonism in a well-structured, prospective cohort. Methods: One hundred and ninety-one FTD patients were enrolled and all patients underwent comprehensive neurological evaluations, neuropsychological tests, and the Unified Parkinson's Disease Rating Scale. Results: The prevalence of parkinsonism was 38.7% (74 patients), and included 33 (46.5%) behavioral variant FTD (bvFTD), 16 (24.2%) semantic dementia (SD), 19 (45.2%) progressive nonfluent aphasia (PNFA), and 6 (50%) FTD associated with motor neuron disease (FTD-MND). SD patients with parkinsonism had higher CDR sum of boxes scores (9.7 +/- 4.5 vs 62 +/- 4.5, p = 0.024), frontal behavioral inventory total score (33.7 +/- 20.5 vs 24.3 +/- 14.5, p = 0.045), and executive function score of frontal executive dysfunction, disinhibition, and apathy (28.9 +/- 13.7 vs 19.2 +/- 12.9, p = 0.021) than those without parkinsonism. Seoul Instrumental Activities of Daily Living score (bvFTD: 23.5 +/- 11.7 vs 17.3 +/- 11.3, p = 0.031, SD: 23.1 +/- 11.1 vs 11.3 +/- 9.3, p = 0.005) was higher for bvFTD and SD with parkinsonism than for those without parkinsonism. Conclusions: Parkinsonism is found to be more common in patients with bvFTD, PNFA, and FTD-MND patients than those with SD. Behavioral disturbances were more prominent in SD with parkinsonism than without. Additional studies are needed to determine the pathomechanism and optimal treatment of parkinsonism in different FTD subtypes. (C) 2016 Elsevier B.V. All rights reserved.
DOI
10.1016/j.jns.2016.11.033
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의학전문대학원 > 의학과 > Journal papers
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