View : 110 Download: 0
Increased plasmacytic differentiation in gastric mucosa associated lymphoid tissue lymphomas: Helicobacter pylori eradication response and IgG4+plasma cell association
- Increased plasmacytic differentiation in gastric mucosa associated lymphoid tissue lymphomas: Helicobacter pylori eradication response and IgG4+plasma cell association
- Park, Sanghui; Ahn, Soomin; Hong, Mineui; Ko, Young Hyeh
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- HUMAN PATHOLOGY
- 0046-8177; 1532-8392
- vol. 59, pp. 113 - 119
- Gastric MALT lymphoma; Helicobacter pylori; IgG4; Treatment response; Plasmacyrio differentiation
- W B SAUNDERS CO-ELSEVIER INC
- SCI; SCIE; SCOPUS
- Gastric mucosa associated lymphoid tissue (MALT) lymphoma is a rare extranodal marginal zone B-cell lymphoma that is often associated with plasmacytic differentiation. However, the clinicopathological characteristics of gastric MALT lymphoma with increased plasmacytic differentiation have not yet been studied. To assess the clinicopathological implications of gastric MALT lymphoma with increased plasmacytic differentiation, 36 cases with increased plasmacytic differentiation and a control group of 16 cases with minimal plasmacytic differentiation were retrospectively collected from 65 primary gastric MALT lymphomas (2010-2012). The hematoxylin and eosin slides were reviewed, and IgG, IgG4, and kappa and lambda immunohistochemical staining was performed. Clinicopathological differences between the 2 groups were compared using the chi(2]) test and odds ratios. Logistic regression analyses were used to evaluate resistance to Helicobacter pylori eradication therapy. Increased plasmacytic differentiation is significantly correlated with the H pylori eradication response (94.4% versus 66.7%, P = .018), lower frequency of relapse (5.6% versus 35.7%, P = .014), the presence of more than one IgG4+ cell per high-power field (27.8% versus 0%, P = .022), and light-chain restriction (33.3% versus 6.2%, P = .044). Univariable logistic regression indicated that negative H pylori status (P = .016) and minimal plasmacytic differentiation (P = .019) were statistically significant predictive factors for resistance to H pylori eradication. Multivariable logistic regression analyses identified no statistically significant predictive factors. However, H pylori negativity and minimal plasmacytic differentiation showed a statistical trend toward significance (P = .078 and P = .09). Gastric MALT lymphomas with increased plasmacytic differentiation have different clinicopathlogical characteristics, and plasmacytic differentiation is associated with H pylori eradication response. (C) 2016 Elsevier Inc. All rights reserved.
- Appears in Collections:
- 의학전문대학원 > 의학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.