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Acupuncture does not protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced damage of dopaminergic neurons in a preclinical mouse model of Parkinson's disease

Title
Acupuncture does not protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced damage of dopaminergic neurons in a preclinical mouse model of Parkinson's disease
Authors
Yang H.-J.Gao Y.Yun J.Y.Kim Y.E.Ehm G.Lee J.Y.Yoon M.-Y.Lee Y.-S.Kim H.-J.Jeon B.
Ewha Authors
윤지영
SCOPUS Author ID
윤지영scopusscopus
Issue Date
2017
Journal Title
NeuroReport
ISSN
0959-4965JCR Link
Citation
vol. 28, no. 1, pp. 50 - 55
Keywords
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridineacupunctureParkinson's diseasestriatumsubstantia nigra
Publisher
Lippincott Williams and Wilkins
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Acupuncture treatment, a complementary and alternative medicine, is associated with a suggested neuroprotective effect in previous preclinical studies of Parkinson's disease (PD); however, results from human clinical trials have been mixed or unsuccessful. Recent systematic reviews of translational neuroprotective studies showed that the supposed efficacy is confounded by low methodological quality, particularly by a lack of randomization and concealed allocation. We sought to replicate previous experimental findings with a study design that mitigates the introduction of bias, including randomization, blinded outcome measures, sham acupuncture application, and allocation concealment by blinded neurotoxin administration. We performed 12 sessions of manual acupuncture at acupoint GB34 (yanglingquan) in mice that were administered the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxin for five consecutive days. In this animal model of PD, acupuncture treatment did not attenuate tyrosine hydroxylase-immunoreactive neuronal death, depletion of striatal dopamine levels, or reduced striatal tyrosine hydroxylase expression. Our results indicate that acupuncture is not neuroprotective against nigrostriatal loss in a subacute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of PD. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.
DOI
10.1097/WNR.0000000000000709
Appears in Collections:
의료원 > 의료원 > Journal papers
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