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Preoperative Assessment of Lymph Node Metastasis in Endometrial Cancer: A Korean Gynecologic Oncology Group Study
- Preoperative Assessment of Lymph Node Metastasis in Endometrial Cancer: A Korean Gynecologic Oncology Group Study
- Kang, Sokbom; Nam, Joo-Hyun; Bae, Duk-Soo; Kim, Jae-Weon; Kim, Moon-Hong; Chen, Xiaojun; No, Jae-Hong; Lee, Jong-Min; Kim, Jae-Hoon; Watari, Hidemich; Kim, Seok Mo; Kim, Sung Hoon; Seong, Seok Ju; Kim, Ki Tae; Kim, Seung Cheol; Kim, Jong-Hyeok; Lim, Myung-Cheol; Lee, Jung-Yun; Ryu, Sang-Young; Yang, Bingyi; Kim, Byoung-Gie
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- 0008-543X; 1097-0142
- vol. 123, no. 2, pp. 263 - 272
- cancer antigen 125 (CA 125); endometrial cancer; lymphadenectomy; lymph node; magnetic resonance imaging; metastasis; prediction; risk factor; surgical staging
- SCI; SCIE; SCOPUS
- BACKGROUND: Previously proposed criteria for preoperatively identifying endometrial cancer patients at lowrisk for lymph nodemetastasis remain to be verified. For this purpose, a prospective, multicenter observational studywas performed. METHODS: Eligible patients with histologically confirmed endometrial cancer underwent magnetic resonance imaging (MRI) and serum cancer antigen 125 (CA 125) testing before surgery. The following criteria were used to identify low-risk patients: 1) endometrioid-type cancer, 2) no evidence of deep myometrial invasion on MRI, 3) no enlarged lymph nodes on MRI, 4) no suspicious metastasis out of the uterine corpus, and 5) serum CA 125 levels less than 35 U/mL. Systematic pelvic and/or para-aortic lymphadenectomy was performed for all patients. The primary endpoint was estimation of the negative predictive value (NPV). RESULTS: From January 2012 to December 2014, 529 patients from20 hospitals in 3 Asian countries were consecutively enrolled. According to our criteria, 272 patients (51.4%) were categorized into the low-risk group. Fifty-three of the 529 patients (10.0%) had lymph node metastases; these patients included 8 (2.9%) falsely categorized as low-risk. The sensitivity and specificity of the criteriawere 84.9% and 55.5%, respectively. The NPVof 97.1% was higher than the predefined target endpoint of 96%. CONCLUSIONS: The low-risk criteria based on preoperative tests were confirmed to be reliable and accurate for identifying patients at low risk for lymph node metastasis. These criteria may facilitate patient counseling and surgical decision making. (C) 2016 American Cancer Society.
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