Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 한수정 | * |
dc.contributor.author | 이원준 | * |
dc.contributor.author | 권오란 | * |
dc.date.accessioned | 2016-12-27T02:12:37Z | - |
dc.date.available | 2016-12-27T02:12:37Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 0531-5565 | * |
dc.identifier.issn | 1873-6815 | * |
dc.identifier.other | OAK-19898 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/233197 | - |
dc.description.abstract | Given the increased concerns about the degenerative decline in the physical performance of the elderly, there is a need for developing effective strategies to suppress the age-related loss of skeletal muscle mass and functional capacity through a lifestyle intervention. This randomized controlled trial examined whether a combination of Korean mistletoe extract (KME) supplement and exercise affected muscle mass, muscle function, and targeted molecular expressions. Sixty-seven subjects aged 55-75 years were assigned to placebo, low-dose (1 g/d), or high-dose (2 g/d) of KME for 12 weeks. The body composition was significantly changed in the high-dose group during the intervention period as determined by skeletal muscle mass (P = 0.040), fat free mass (P = 0.042), soft lean mass (P = 0.023), skeletal muscle index (P = 0.041), fat-free mass index (P = 0.030), percent body fat (P = 0.044), and fat mass to lean mass ratio (P = 0.030). Knee strength was measured by Cybex, demonstrating a significant effect in the KME groups compared to the placebo group (P = 0.026 for peak torque and P = 0.057 for set total work), which was more pronounced after adjusting for age, gender, protein, and energy intake (P = 0.009 for peak torque and P = 0.033 for set total work). The dynamic balance ability was remarkably improved in the high-dose group over a 12-week period as determined by Timed "Up and Go" (P = 0.005 for fast walk test and P = 0.024 for ordinary walk test). Consistent with these results, RT-PCR, multiplex analyses, and immunocytofluorescence staining revealed that a high-dose KME supplementation was effective for suppressing intracellular pathways related to muscle protein degradation, but stimulating those related to myogenesis. In particular, significant differences were found in atrogin-1 mRNA (P = 0.002 at a single administration and P = 0.001 at a 12-week administration), myogenin mRNA (P < 0.0001 at a single administration and P = 0.040 at a 12-week administration), and insulin growth factor 1 receptor phosphorylation (P = 0.002 at a 12 week administration). These results suggest that KME supplementation together with resistance exercise may be useful in suppressing the age-related loss of muscle mass and strength in the elderly. (C) 2016 Elsevier Inc. All rights reserved. | * |
dc.language | English | * |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | * |
dc.subject | Elderly | * |
dc.subject | Mistletoe | * |
dc.subject | Muscle mass | * |
dc.subject | Muscle function | * |
dc.subject | Muscle biopsy | * |
dc.subject | Targeted gene analysis | * |
dc.title | A combination of Korean mistletoe extract and resistance exercise retarded the decline in muscle mass and strength in the elderly: A randomized controlled trial | * |
dc.type | Article | * |
dc.relation.volume | 87 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 48 | * |
dc.relation.lastpage | 56 | * |
dc.relation.journaltitle | EXPERIMENTAL GERONTOLOGY | * |
dc.identifier.doi | 10.1016/j.exger.2016.11.003 | * |
dc.identifier.wosid | WOS:000393528000007 | * |
dc.identifier.scopusid | 2-s2.0-85000977792 | * |
dc.author.google | Lim, Nam Ju | * |
dc.author.google | Shin, Jun Ho | * |
dc.author.google | Kim, Hye Jin | * |
dc.author.google | Lim, Yeni | * |
dc.author.google | Kim, Ji Yeon | * |
dc.author.google | Lee, Won Jun | * |
dc.author.google | Han, Soo Jeong | * |
dc.author.google | Kwon, Oran | * |
dc.contributor.scopusid | 한수정(57217617482) | * |
dc.contributor.scopusid | 이원준(55934371200) | * |
dc.contributor.scopusid | 권오란(55713470100) | * |
dc.date.modifydate | 20240123093411 | * |