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Serum levels of persistent organic pollutants and insulin secretion among children age 7–9 years: A prospective cohort study

Title
Serum levels of persistent organic pollutants and insulin secretion among children age 7–9 years: A prospective cohort study
Authors
Park S.H.Ha E.Hong Y.S.Park H.
Ewha Authors
하은희박혜숙홍영선
SCOPUS Author ID
하은희scopus; 박혜숙scopus; 홍영선scopus
Issue Date
2016
Journal Title
Environmental Health Perspectives
ISSN
0091-6765JCR Link
Citation
vol. 124, no. 12, pp. 1924 - 1930
Publisher
Public Health Services, US Dept of Health and Human Services
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Background: Persistent organic pollutants (POPs) are endocrine disruptors and have been suggested as possible risk factors for diabetes. Few studies have been performed to investigate this association among children. oBjectives: In this study, we prospectively examined the relationship between the serum concentration of POPs and glucose metabolism in children. Methods: Data were collected from the Ewha Birth & Growth Cohort Study, an ongoing birth cohort study initially constructed between 2001 and 2006. In 2010–2012, the POP concentration was measured in serum from a total of 214 children, 7–9 years of age. Using fasting glucose and insulin measurements at both baseline and the second year of follow-up, the homeostatic model assessment of beta-cell function (HOMA-β) and homeostatic model assessment of insulin resistance (HOMA-IR) were calculated. Multiple linear regression analysis and a linear mixed-effects model were used to determine the relationship between POP tertiles and metabolic biomarkers. results: Compared with the lowest tertile of total marker PCBs, participants in the third tertile had decreased HOMA-β values, after adjustment for age, sex, body mass index z-score, mother’s education, ponderal index, and history of breastfeeding (–18.94%; 95% CI: –32.97%, –1.98%). In a linear mixed model, the HOMA-β values were still lower in subjects in the highest compared with the lowest tertile of total PCBs at the 2-year follow-up period (108.3 vs. 135.0, respectively). conclusion: The results of the study suggested that exposure to POPs among children might affect insulin secretory function, which could lead to an increased risk of developing diabetes. © 2016, Environmental Health Perspectives. All rights reserved.
DOI
10.1289/EHP147
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의학전문대학원 > 의학과 > Journal papers
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