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Serum levels of persistent organic pollutants and insulin secretion among children age 7–9 years: A prospective cohort study
- Title
- Serum levels of persistent organic pollutants and insulin secretion among children age 7–9 years: A prospective cohort study
- Authors
- Park S.H.; Ha E.; Hong Y.S.; Park H.
- Ewha Authors
- 하은희; 박혜숙; 홍영선
- SCOPUS Author ID
- 하은희; 박혜숙; 홍영선
- Issue Date
- 2016
- Journal Title
- Environmental Health Perspectives
- ISSN
- 0091-6765
- Citation
- Environmental Health Perspectives vol. 124, no. 12, pp. 1924 - 1930
- Publisher
- Public Health Services, US Dept of Health and Human Services
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Background: Persistent organic pollutants (POPs) are endocrine disruptors and have been suggested as possible risk factors for diabetes. Few studies have been performed to investigate this association among children. oBjectives: In this study, we prospectively examined the relationship between the serum concentration of POPs and glucose metabolism in children. Methods: Data were collected from the Ewha Birth & Growth Cohort Study, an ongoing birth cohort study initially constructed between 2001 and 2006. In 2010–2012, the POP concentration was measured in serum from a total of 214 children, 7–9 years of age. Using fasting glucose and insulin measurements at both baseline and the second year of follow-up, the homeostatic model assessment of beta-cell function (HOMA-β) and homeostatic model assessment of insulin resistance (HOMA-IR) were calculated. Multiple linear regression analysis and a linear mixed-effects model were used to determine the relationship between POP tertiles and metabolic biomarkers. results: Compared with the lowest tertile of total marker PCBs, participants in the third tertile had decreased HOMA-β values, after adjustment for age, sex, body mass index z-score, mother’s education, ponderal index, and history of breastfeeding (–18.94%; 95% CI: –32.97%, –1.98%). In a linear mixed model, the HOMA-β values were still lower in subjects in the highest compared with the lowest tertile of total PCBs at the 2-year follow-up period (108.3 vs. 135.0, respectively). conclusion: The results of the study suggested that exposure to POPs among children might affect insulin secretory function, which could lead to an increased risk of developing diabetes. © 2016, Environmental Health Perspectives. All rights reserved.
- DOI
- 10.1289/EHP147
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
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