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Antimicrobial activity of lactobacillus strains against uropathogens

Title
Antimicrobial activity of lactobacillus strains against uropathogens
Authors
Shim, Yoon HeeLee, Seung JooLee, Jung Won
Ewha Authors
이승주이정원
SCOPUS Author ID
이승주scopusscopus; 이정원scopus
Issue Date
2016
Journal Title
PEDIATRICS INTERNATIONAL
ISSN
1328-8067JCR Link1442-200XJCR Link
Citation
vol. 58, no. 10, pp. 1009 - 1013
Keywords
antibiotic discinhibitory zonelactobacillusurinary tract infectionuropathogen
Publisher
WILEY-BLACKWELL
Indexed
SCIE; SCOPUS WOS scopus
Abstract
BackgroundThe use of lactobacillus probiotics has been proposed as an alternative to prophylactic antibiotics for preventing urinary tract infection (UTI) in the era of antibiotic resistance. In this study, the antimicrobial activity of lactobacillus strains against uropathogens, was evaluated and compared with that of antibiotics. MethodsTo evaluate inhibitory activities of lactobacilli against uropathogens, six lactobacillus strains (L. gasseri, L. rhamnosus, L. acidophilus, L. plantarum, L. paracasei, L. acidophilus) and four representative uropathogens of infantile UTI (extended-spectrum beta-lactamase [ESBL](-) Escherichia coli, ESBL(+) E. coli, Proteus vulgaris, Enterococcus fecalis) were selected. Lactobacillus strain in vitro inhibition of each uropathogen was evaluated on MRS agar well diffusion assay and compared with that of commercial antibiotic discs. ResultsAverage inhibitory zone for each of the six lactobacillus strains against the four uropathogens showed slightly different but consistent inhibition (inhibitory zone diameter, 10.5-20.0 mm). This was different to that of the antibiotic discs, which had a wider range of inhibition (inhibitory zone diameter, <6.0-27.5 mm) depending on the uropathogen resistance pattern. The inhibitory zone of the six lactobacillus strains was between that of sensitive and resistant antibiotics (P < 0.05). ConclusionsLactobacillus strains had similar moderate antimicrobial activities against uropathogens. Further research is needed to ascertain the strains with the best probiotic potential.
DOI
10.1111/ped.12949
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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