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Does salpingectomy have a deleterious impact on ovarian response in in vitro fertilization cycles?

Title
Does salpingectomy have a deleterious impact on ovarian response in in vitro fertilization cycles?
Authors
Yoon, Sang-HeeLee, Ji YoungKim, Soo-NyungChung, Hye WonPark, So YunLee, Chulmin
Ewha Authors
정혜원
SCOPUS Author ID
정혜원scopus
Issue Date
2016
Journal Title
FERTILITY AND STERILITY
ISSN
0015-0282JCR Link1556-5653JCR Link
Citation
vol. 106, no. 5, pp. 1083 - +
Keywords
Salpingectomyovarian responsein vitro fertilization
Publisher
ELSEVIER SCIENCE INC
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Objective: To investigate the impact of salpingectomy in patients with IVF treatment on ovarian response. Design: Meta-analysis. Setting: Not applicable. Patient(s): Patients under treatment for infertility, during the cycles before and after treatment by salpingectomy for hydrosalpinx or ectopic pregnancy. Intervention(s): PubMed, MEDLINE, EMBASE databases, and CENTRAL in Cochrane Library up to July 2015. Either a fixed-or a random-effects model was used to calculate the overall combined risk estimates. The subgroup analysis was planned a priori before data were collected and analyzed. Main Outcome Measure(s): The amount of gonadotropin administered, the peak E-2 level, the number of oocytes retrieved, and the number of pregnancies. Result(s): After the final screening, 12 of the studies were retrospective and six were prospective. In this meta-analysis, 1,482 patients were enrolled, including a total of 657 patients with salpingectomy and 825 without salpingectomy. The comparisons before and after salpingectomy of the peak E-2 level (standardized mean difference [SMD] = -0.182; 95% confidence interval [CI], -0.166, 0.101; I-2, 85.45%), the total gonadotropin dose used for stimulation (SMD = 0.127; 95% CI, -0.054 0.308; I-2, 84.49%), and number of oocytes retrieved (SMD = -0.060; 95% CI, -.189, 0.070; I-2, 63.93%) did not reveal any significant differences. The number of pregnancies before and after salpingectomy did not differ significantly (odds ratio [OR] = 1.180; 95% CI, 0.854, 1.630; I-2, 34.01%). Conclusion(s): Salpingectomy in infertile patients does not have any negative effect on their subsequent fertility treatment, but further studies should be performed before this result can be considered definitive. (C) 2016 by American Society for Reproductive Medicine.
DOI
10.1016/j.fertnstert.2016.05.030
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의학전문대학원 > 의학과 > Journal papers
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