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Assessment of scoring systems for acute-on-chronic liver failure at predicting short-Term mortality in patients with

Title
Assessment of scoring systems for acute-on-chronic liver failure at predicting short-Term mortality in patients with
Authors
Kim H.Y.Kim C.W.Kim T.Y.Song D.S.Sinn D.H.Yoon E.L.Jung Y.K.Suk K.T.Lee S.S.Lee C.H.Kim T.H.Kim J.H.Yim H.J.Kim S.E.Baik S.K.Lee B.S.Jang J.Y.Kim Y.S.Kim S.G.Yang J.M.Sohn J.H.Lee H.J.Park S.H.Choi E.H.Kim D.J.
Ewha Authors
김태헌
SCOPUS Author ID
김태헌scopus
Issue Date
2016
Journal Title
World Journal of Gastroenterology
ISSN
1007-9327JCR Link
Citation
vol. 22, no. 41, pp. 9205 - 9213
Keywords
Acute-on-chronic liver failureAlcoholic hepatitisMortalityPrognosisScoring system
Publisher
Baishideng Publishing Group Co., Limited
Indexed
SCIE; SCOPUS WOS scopus
Abstract
AIM To assess the performance of proposed scores specific for acute-on-chronic liver failure in predicting shortterm mortality among patients with alcoholic hepatitis. METHODS We retrospectively collected data from 264 patients with clinically diagnosed alcoholic hepatitis from January to December 2013 at 21 academic hospitals in Korea. The performance for predicting short-Term mortality was calculated for Chronic Liver Failure- Sequential Organ Failure Assessment (CLIF-SOFA), CLIF Consortium Organ Failure score (CLIF-C OFs), Maddrey's discriminant function (DF), age, bilirubin, international normalized ratio and creatinine score (ABIC), Glasgow Alcoholic Hepatitis Score (GAHS), model for end-stage liver disease (MELD), and MELD-Na. RESULTS Of 264 patients, 32 (12%) patients died within 28 d. The area under receiver operating characteristic curve of CLIF-SOFA, CLIF-C OFs, DF, ABIC, GAHS, MELD, and MELD-Na was 0.86 (0.81-0.90), 0.89 (0.84-0.92), 0.79 (0.74-0.84), 0.78 (0.72-0.83), 0.81 (0.76-0.86), 0.83 (0.78-0.88), and 0.83 (0.78-0.88), respectively, for 28-d mortality. The performance of CLIF-SOFA had no statistically significant differences for 28-d mortality. The performance of CLIF-C OFs was superior to that of DF, ABIC, and GAHS, while comparable to that of MELD and MELD-Na in predicting 28-d mortality. A CLIF-SOFA score of 8 had 78.1% sensitivity and 79.7% specificity, and CLIF-C OFs of 10 had 68.8% sensitivity and 91.4% specificity for predicting 28-d mortality. CONCLUSION CLIF-SOFA and CLIF-C OF scores performed well, with comparable predictive ability for short-Term mortality compared to the commonly used scoring systems in patients with alcoholic hepatitis. © 2016 Baishideng Publishing Group Inc. All rights reserved.
DOI
10.3748/wjg.v22.i41.9205
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의과대학 > 의학과 > Journal papers
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