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Highly elevated serum lactate dehydrogenase is associated with central nervous system relapse in patients with diffuse large B-cell lymphoma: Results of a multicenter prospective cohort study

Title
Highly elevated serum lactate dehydrogenase is associated with central nervous system relapse in patients with diffuse large B-cell lymphoma: Results of a multicenter prospective cohort study
Authors
Kim, Seok JinHong, Jun SikChang, Myung HeeKim, Jeong-AKwak, Jae-YongKim, Jin SeokYoon, Dok HyunLee, Won SikDo, Young RokKang, Hye JinEom, Hyeon-SeokPark, YongWon, Jong-HoMun, Yeung-ChulKim, Hyo JungKwon, Jung HyeKong, Jee HyunOh, Sung YongLee, SunahBae, Sung HwaYang, Deok-HwanJun, Hyun JungKim, Yang SooYun, Hwan JungLee, Soon IlKim, Min KyoungPark, Eun KyungKim, Won SeogSuh, Cheolwon
Ewha Authors
문영철
SCOPUS Author ID
문영철scopus
Issue Date
2016
Journal Title
ONCOTARGET
ISSN
1949-2553JCR Link
Citation
vol. 7, no. 44, pp. 72033 - 72043
Keywords
diffuse large B-cell lymphomacentral nervous systemprognosislactate dehydrogenase
Publisher
IMPACT JOURNALS LLC
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Central nervous system involvement remains a challenging issue in the treatment of patients with diffuse large B-cell lymphoma. We conducted a prospective cohort study with newly diagnosed diffuse large B-cell lymphoma patients receiving rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone to identify incidence and risk factors for central nervous system involvement. Among 595 patients, 279 patients received pre-treatment central nervous system evaluation, and 14 patients had central nervous system involvement at diagnosis (2.3% out of entire patients and 5.0% out of the 279 patients). For those patients, median follow-up duration was 38.2 months and some of them achieved long-term survival. Out of 581 patients who did not have central nervous system involvement at diagnosis, 26 patients underwent secondary central nervous system relapse with a median follow-up of 35 months, and the median time to central nervous system involvement was 10.4 months (range: 3.4-29.2). Serum lactate dehydrogenase > x3 upper limit of normal range, the Eastern Cooperative Oncology Group performance status >= 2, and involvement of sinonasal tract or testis, were independent risk factors for central nervous system relapse in multivariate analysis. Our study suggests that enhanced stratification of serum lactate dehydrogenase according to the National Comprehensive Cancer Network-International Prognostic Index may contribute to better prediction for central nervous system relapse in patients with diffuse large B-cell lymphoma.
DOI
10.18632/oncotarget.12459
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의학전문대학원 > 의학과 > Journal papers
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