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Dietary vitamin C intake protects against COPD: the Korea National Health and Nutrition Examination Survey in 2012
- Title
- Dietary vitamin C intake protects against COPD: the Korea National Health and Nutrition Examination Survey in 2012
- Authors
- Park, Hye Jung; Byun, Min Kwang; Kim, Hyung Jung; Kim, Jae Yeol; Kim, Yu-Il; Yoo, Kwang-Ha; Chun, Eun Mi; Jung, Ji Ye; Lee, Sang Haak; Ahn, Chul Min|Korean Smoking Cessation Study Grp
- Ewha Authors
- 천은미
- SCOPUS Author ID
- 천은미
- Issue Date
- 2016
- Journal Title
- INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
- ISSN
- 1178-2005
- Citation
- INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE vol. 11, pp. 2721 - 2728
- Keywords
- chronic obstructive lung disease; vitamin C; nutrition; risk factor; smoking
- Publisher
- DOVE MEDICAL PRESS LTD
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Background: Vitamin C, as an antioxidant, has recently been suggested to provide protection against COPD; however, only few national cohort studies have investigated these effects. We aimed to confirm the protective effects of vitamin C against COPD in Korean patients. Patients and methods: We analyzed the data of 3,283 adults aged >= 40 years (representing 23,541,704 subjects) who underwent pulmonary function tests and responded to questionnaires on smoking history and vitamin C intake, with stratification variables and sampling weight designated by the Korea 2012 National Health and Nutrition Examination Survey. Results: Among all the subjects, 512 (representing 3,459,679 subjects; 15.6%) were diagnosed as having COPD based on pulmonary function test results. Male gender, old age, residence in suburban/rural regions, low household income, low educational level, an occupation in agriculture or fisheries, and heavy smoking were significantly associated with COPD. Low intake of nutrients, including potassium, vitamin A, carotene, retinol, and vitamin C, was significantly associated with COPD. The prevalence of COPD in heavy smokers with the lowest quartile (Q1, <48.50 mg; 63.0%) and low-middle quartile (Q2, 48.50-84.38 mg; 56.4%) of vitamin C intake was significantly higher than that in subjects with the high-middle quartile (Q3, 84.38-141.63 mg; 29.5%) and highest quartile (Q4, >141.63 mg; 32.6%) of vitamin C intake (P=0.015). In multivariate analysis, male gender, old age, heavy smoking, and a low intake of vitamin C were significant independent risk factors for COPD. A significant reduction of 76.7% in COPD risk was observed with a Q3 vitamin C intake compared to Q1 vitamin C intake (odds ratio, 0.233; 95% confidence interval, 0.094-0.576) in heavy smokers. Conclusion: This large-scale national study suggests that dietary vitamin C provides protection against COPD, independent of smoking history, in the general Korean population.
- DOI
- 10.2147/COPD.S119448
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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