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Probiotics prophylaxis in pyelonephritis infants with normal urinary tracts

Title
Probiotics prophylaxis in pyelonephritis infants with normal urinary tracts
Authors
Lee S.J.Cha J.Lee J.W.
Ewha Authors
이승주차지혜
SCOPUS Author ID
이승주scopusscopus; 차지혜scopus
Issue Date
2016
Journal Title
World Journal of Pediatrics
ISSN
1708-8569JCR Link
Citation
vol. 12, no. 4, pp. 425 - 429
Keywords
antibiotic prophylaxisantibiotic resistanceprobiotic prophylaxispyelonephritis
Publisher
Institute of Pediatrics of Zhejiang University
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Background: Pyelonephritis in infants is considered as a major factor for the formation of renal scar. To prevent recurrent pyelonephritis and renal damage, prophylaxis is extremely important. The aim of this study was to compare the effectiveness of probiotic and antibiotic prophylaxis or no-prophylaxis in infants with pyelonephritis and normal urinary tract. Methods: Altogether 191 infants, who were diagnosed with acute pyelonephritis, proven to have normal urinary tracts and followed up for 6 months on prophylaxis, were retrospectively evaluated. According to the types of prophylaxis, the infants were divided into three groups [probiotics (Lactobacillus species), antibiotics (trimethoprim/sulfamethoxazole, TMP/SMX), and noprophylaxis]. The incidence of recurrent urinary tract infection (UTI) during 6 months after the development of pyelonephritis, main causative uropathogens, and its antimicrobial sensitivities were compared. Results: The incidence of recurrent UTI in the probiotic group was 8.2%, which was significantly lower than 20.6% in the no-prophylaxis group (P=0.035) and was not significantly different from 10.0% of the antibiotic group (P=0.532). The significant difference between the probiotic and no-prophylaxis groups was seen only in male infants (P=0.032). The main causative organism of recurrent UTI was Escherichia coli (E.coli), which was not different among the three groups (P=0.305). The resistance rate of E. coli to TMP/SMX was 100% in the antibiotic group, which was significantly higher than 25.0% in the probiotic group and 41.7% in the no-prophylaxis group (P=0.008). Conclusion: Probiotic prophylaxis was more effective in infants with pyelonephritis and normal urinary tract than in those with no-prophylaxis. It could be used as a natural alternative to antibiotic prophylaxis. © 2016, Children's Hospital, Zhejiang University School of Medicine and Springer-Verlag Berlin Heidelberg.
DOI
10.1007/s12519-016-0013-2
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의학전문대학원 > 의학과 > Journal papers
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