Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오세관 | * |
dc.date.accessioned | 2016-12-13T02:12:26Z | - |
dc.date.available | 2016-12-13T02:12:26Z | - |
dc.date.issued | 2008 | * |
dc.identifier.issn | 0022-2623 | * |
dc.identifier.other | OAK-4930 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/233100 | - |
dc.description.abstract | An efficient synthesis involving a key aldol reaction and biological properties of 1,3-diphenyl-2-propen-1-ones 8-20 is described. The in vitro activity for 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging of 10 and 11 was 2 times higher than that for resveratrol. Compounds 9 and 11 were the strongest in suppression of in vitro nitric oxide (NO) generation and antiexcitotoxicity. Molecular modeling proposes an electron-donating group at the para position of acetophenones that leads to a dramatic increase in the suppression of NO production. © 2008 American Chemical Society. | * |
dc.language | English | * |
dc.title | Efficient synthesis and neuroprotective effect of substituted 1,3-diphenyl-2-propen-1-ones | * |
dc.type | Article | * |
dc.relation.issue | 13 | * |
dc.relation.volume | 51 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 4054 | * |
dc.relation.lastpage | 4058 | * |
dc.relation.journaltitle | Journal of Medicinal Chemistry | * |
dc.identifier.doi | 10.1021/jm800221g | * |
dc.identifier.wosid | WOS:000257391000039 | * |
dc.identifier.scopusid | 2-s2.0-46849086780 | * |
dc.author.google | Jung J.-C. | * |
dc.author.google | Jang S. | * |
dc.author.google | Lee Y. | * |
dc.author.google | Min D. | * |
dc.author.google | Lim E. | * |
dc.author.google | Jung H. | * |
dc.author.google | Oh M. | * |
dc.author.google | Oh S. | * |
dc.author.google | Jung M. | * |
dc.contributor.scopusid | 오세관(7404103757) | * |
dc.date.modifydate | 20240118133340 | * |