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의과대학
의학과
Journal papers
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Efficient synthesis and neuroprotective effect of substituted 1,3-diphenyl-2-propen-1-ones
Title
Efficient synthesis and neuroprotective effect of substituted 1,3-diphenyl-2-propen-1-ones
Authors
Jung J.-C.
;
Jang S.
;
Lee Y.
;
Min D.
;
Lim E.
;
Jung H.
;
Oh M.
;
Oh S.
;
Jung M.
Ewha Authors
오세관
SCOPUS Author ID
오세관
Issue Date
2008
Journal Title
Journal of Medicinal Chemistry
ISSN
0022-2623
Citation
Journal of Medicinal Chemistry vol. 51, no. 13, pp. 4054 - 4058
Indexed
SCI; SCIE; SCOPUS
Document Type
Article
Abstract
An efficient synthesis involving a key aldol reaction and biological properties of 1,3-diphenyl-2-propen-1-ones 8-20 is described. The in vitro activity for 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging of 10 and 11 was 2 times higher than that for resveratrol. Compounds 9 and 11 were the strongest in suppression of in vitro nitric oxide (NO) generation and antiexcitotoxicity. Molecular modeling proposes an electron-donating group at the para position of acetophenones that leads to a dramatic increase in the suppression of NO production. © 2008 American Chemical Society.
DOI
10.1021/jm800221g
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