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Efficient synthesis and neuroprotective effect of substituted 1,3-diphenyl-2-propen-1-ones

Title
Efficient synthesis and neuroprotective effect of substituted 1,3-diphenyl-2-propen-1-ones
Authors
Jung J.-C.Jang S.Lee Y.Min D.Lim E.Jung H.Oh M.Oh S.Jung M.
Ewha Authors
오세관
SCOPUS Author ID
오세관scopus
Issue Date
2008
Journal Title
Journal of Medicinal Chemistry
ISSN
0022-2623JCR Link
Citation
vol. 51, no. 13, pp. 4054 - 4058
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
An efficient synthesis involving a key aldol reaction and biological properties of 1,3-diphenyl-2-propen-1-ones 8-20 is described. The in vitro activity for 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging of 10 and 11 was 2 times higher than that for resveratrol. Compounds 9 and 11 were the strongest in suppression of in vitro nitric oxide (NO) generation and antiexcitotoxicity. Molecular modeling proposes an electron-donating group at the para position of acetophenones that leads to a dramatic increase in the suppression of NO production. © 2008 American Chemical Society.
DOI
10.1021/jm800221g
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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