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Controlled release of donepezil intercalated in smectite clays

Title
Controlled release of donepezil intercalated in smectite clays
Authors
Park J.K.Choy Y.B.Oh J.-M.Kim J.Y.Hwang S.-J.Choy J.-H.
Ewha Authors
최진호황성주
SCOPUS Author ID
최진호scopus; 황성주scopus
Issue Date
2008
Journal Title
International Journal of Pharmaceutics
ISSN
0378-5173JCR Link
Citation
vol. 359, no. 41276, pp. 198 - 204
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The inorganic-organic hybrid for a drug delivery system was successfully realized by intercalating donepezil molecules into smectite clays (laponite XLG, saponite, and montmorillonite). According to the powder XRD patterns, TG profiles, and FT-IR spectra, itwas confirmed that donepezil moleculeswerewell stabilized in the interlayer space of clay via mono or double layer stacking. The adsorption amount and molecular structure of donepezil appeared to depend on the cation exchange capacity of the clay, which in turn, tailored the drug release patterns. Especially in the presence of a bulky cationic polymer (Eudragit® E-100) in the releasemedia, the release ratewas found to be improved due to its effective replacement with intercalated donepezil molecules. Therefore, to formulate a complete drug delivery system, the hybrids were coated with Eudragit® E-100 using a spray dryer, which also showed great enhancement in the release rate during a short period of time (180 min). © 2008 Elsevier B.V.
DOI
10.1016/j.ijpharm.2008.04.012
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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