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Itraconazole-Laponite: Kinetics and mechanism of drug release

Title
Itraconazole-Laponite: Kinetics and mechanism of drug release
Authors
Jung H.Kim H.-M.Choy Y.B.Hwang S.-J.Choy J.-H.
Ewha Authors
최진호황성주
SCOPUS Author ID
최진호scopus; 황성주scopus
Issue Date
2008
Journal Title
Applied Clay Science
ISSN
0169-1317JCR Link
Citation
vol. 40, no. 41278, pp. 99 - 107
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A clay-drug nanohybrid was prepared by interfacial boundary ion exchange reaction, from which the release mechanism of a poorly water soluble drug, itraconazole, was studied systematically. The effect of cation types on drug release was investigated on the basis of a UPS 25 guide line and the effect of Laponite dissolution was also studied at pH = 1.2. To describe the release patterns, mathematical modeling was preformed using first-order, Elovich, parabolic diffusion, and power function equations. © 2007 Elsevier B.V. All rights reserved.
DOI
10.1016/j.clay.2007.09.002
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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