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Synthesis and biological evaluation of trisubstituted imidazole derivatives as inhibitors of p38α mitogen-activated protein kinase

Title
Synthesis and biological evaluation of trisubstituted imidazole derivatives as inhibitors of p38α mitogen-activated protein kinase
Authors
Kim D.-K.Lim J.-H.Lee J.A.Dewang P.M.
Ewha Authors
김대기
SCOPUS Author ID
김대기scopus
Issue Date
2008
Journal Title
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894XJCR Link
Citation
vol. 18, no. 14, pp. 4006 - 4010
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A series of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety have been synthesized and evaluated for p38α MAP kinase inhibitory activity. Among them, compounds 22c, 27b, and 28b inhibited p38α MAP kinase with IC50 values 27.6, 28, and 31 nM, respectively. © 2008 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmcl.2008.06.007
Appears in Collections:
약학대학 > 약학과 > Journal papers
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