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Outbreak of rotavirus variant P[8] in Seoul, South Korea
- Title
- Outbreak of rotavirus variant P[8] in Seoul, South Korea
- Authors
- Lee J.-I.; Song M.-O.; Chung J.-Y.; Han T.-H.; Ahn Y.-M.; Seo J.-W.; Kim M.-S.; Kim M.-Y.; Kim W.-Y.; Lee C.-H.
- Ewha Authors
- 서정완
- SCOPUS Author ID
- 서정완
- Issue Date
- 2008
- Journal Title
- Journal of Medical Virology
- ISSN
- 0146-6615
- Citation
- Journal of Medical Virology vol. 80, no. 9, pp. 1661 - 1665
- Indexed
- SCI; SCIE; SCOPUS
- Document Type
- Article
- Abstract
- An epidemiologic study was performed to determine the genetic variability of rotaviruses in Seoul, South Korea. In 3,174 stool specimens from children with acute diarrhea at five referral hospitals, 571 (18%) possessed the antigen of group A rotavirus detectable by ELISA - 10.8% in 2004 and 28.1% in 2005. VP7 genotyping revealed that the G3 type was found in 25.6% of all typed isolates, G4 in 23.8%, G2 in 21.6%, and G1 in 17.6%. VP4 genotyping showed that the P[8] type was detected in 66.7%, P[6] in 15.6%, P[4] in 13.0%, and P[9] in 0.2%. Because the variant P[8] type could not be amplified initially by conventional P typing primers (1T-1), PCR were performed using newly designed 1T-1S primer, which revealed that 307 specimens were the variant P[8] type. Uncommon combinations such as G4P[6] and G2P[8] were also found with relatively high prevalence, 14.6% and 12.8%, respectively. Variant P[8] types were associated with an outbreak of rotavirus in 2005. © 2008 Wiley-Liss, Inc.
- DOI
- 10.1002/jmv.21256
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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