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Outbreak of rotavirus variant P[8] in Seoul, South Korea

Title
Outbreak of rotavirus variant P[8] in Seoul, South Korea
Authors
Lee J.-I.Song M.-O.Chung J.-Y.Han T.-H.Ahn Y.-M.Seo J.-W.Kim M.-S.Kim M.-Y.Kim W.-Y.Lee C.-H.
Ewha Authors
서정완
SCOPUS Author ID
서정완scopus
Issue Date
2008
Journal Title
Journal of Medical Virology
ISSN
0146-6615JCR Link
Citation
vol. 80, no. 9, pp. 1661 - 1665
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
An epidemiologic study was performed to determine the genetic variability of rotaviruses in Seoul, South Korea. In 3,174 stool specimens from children with acute diarrhea at five referral hospitals, 571 (18%) possessed the antigen of group A rotavirus detectable by ELISA - 10.8% in 2004 and 28.1% in 2005. VP7 genotyping revealed that the G3 type was found in 25.6% of all typed isolates, G4 in 23.8%, G2 in 21.6%, and G1 in 17.6%. VP4 genotyping showed that the P[8] type was detected in 66.7%, P[6] in 15.6%, P[4] in 13.0%, and P[9] in 0.2%. Because the variant P[8] type could not be amplified initially by conventional P typing primers (1T-1), PCR were performed using newly designed 1T-1S primer, which revealed that 307 specimens were the variant P[8] type. Uncommon combinations such as G4P[6] and G2P[8] were also found with relatively high prevalence, 14.6% and 12.8%, respectively. Variant P[8] types were associated with an outbreak of rotavirus in 2005. © 2008 Wiley-Liss, Inc.
DOI
10.1002/jmv.21256
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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