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The expression of molecular mediators in the idiopathic cutaneous calcification and ossification

Title
The expression of molecular mediators in the idiopathic cutaneous calcification and ossification
Authors
Kim S.Y.Choi H.Y.Myung K.B.Choi Y.W.
Ewha Authors
명기범최혜영최유원
SCOPUS Author ID
명기범scopusscopus; 최혜영scopus; 최유원scopus
Issue Date
2008
Journal Title
Journal of Cutaneous Pathology
ISSN
0303-6987JCR Link
Citation
vol. 35, no. 9, pp. 826 - 831
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Background: Idiopathic cutaneous calcification and ossification occur in the absence of an abnormal serum calcium level or pre-existing tissue abnormality. The pathogenesis has not been fully elucidated. The aim of this study was to investigate the expression of several molecular mediators in the idiopathic cutaneous calcification and ossification. Methods: Immunohistochemical study was used to evaluate the expression of molecular mediators, bone morphogenetic protein 4 (BMP-4), β-catenin, osteopontin, osteonectin and osteocalcin, and cell markers, smooth muscle actin, CD29 and CD44. And confocal laser scanning microscopy was used to evaluate the colocalization of BMP-4 and BMP receptor type IA. Results: BMP-4, β-catenin, osteopontin, osteonectin and osteocalcin were expressed on the calcified and ossified tissue. Especially, BMP-4 was expressed on the surrounding mesenchymal cells. Smooth muscle actin positive mesenchymal cells were on around the immature ossified tissue. Mesenchymal stem cell markers, CD29 and CD44 were not expressed. Conclusion: Our data suggest that BMP-4, β-catenin, osteopontin, osteonectin and osteocalcin may be involved in the idiopathic cutaneous calcification and ossification. And smooth muscle actin positive mesenchymal cells may be involved in the cutaneous ossification. This study suggests that the idiopathic cutaneous calcification and ossification is highly complicated and regulated active process like ectopic calcification of other tissues. © Blackwell Munksgaard 2007.
DOI
10.1111/j.1600-0560.2007.00904.x
Appears in Collections:
의과대학 > 의학과 > Journal papers
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