Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 한평림 | - |
dc.date.accessioned | 2016-12-06T02:12:27Z | - |
dc.date.available | 2016-12-06T02:12:27Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0006-3223 | - |
dc.identifier.other | OAK-4997 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/233030 | - |
dc.description.abstract | Background: Adenylyl cyclases (ACs) represent a diverse family of enzymes responsible for the generation of cyclic adenosine monophosphate (cAMP), a key intracellular second messenger. The Ca2+/calmodulin-stimulated AC1 and AC8 isoforms as well as the calcium-inhibited AC5 isoform are abundantly expressed within limbic regions of the central nervous system. This study examines the contribution of these AC isoforms to emotional behavior. Methods: Male and female AC1/8 double knockout mice (DKO) and AC5 knockout mice (AC5KO) were examined on a series of standard laboratory assays of emotionality. Mice were also assayed for hippocampal cell proliferation and for changes in brain-derived neurotrophic factor signaling in the nucleus accumbens, amygdala, and hippocampus, three forebrain structures involved in the regulation of mood and affect. Results: The AC5KO mice showed striking anxiolytic and antidepressant phenotypes on standard behavioral assays. In contrast, AC1/8 DKO mice were hypoactive, exhibited diminished sucrose preference, and displayed alterations in neurotrophic signaling, generally consistent with a prodepressant phenotype. Neither line of mice displayed alterations in hippocampal cell proliferation. Conclusions: These data illustrate the complex manner in which Ca2+/calmodulin-stimulated ACs contribute to emotional behavior. In addition, they support the possibility that a selective AC5 antagonist would be of therapeutic value against depression and anxiety disorders. © 2008 Society of Biological Psychiatry. | - |
dc.language | English | - |
dc.title | Calcium-Sensitive Adenylyl Cyclases in Depression and Anxiety: Behavioral and Biochemical Consequences of Isoform Targeting | - |
dc.type | Article | - |
dc.relation.issue | 4 | - |
dc.relation.volume | 64 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 336 | - |
dc.relation.lastpage | 343 | - |
dc.relation.journaltitle | Biological Psychiatry | - |
dc.identifier.doi | 10.1016/j.biopsych.2008.03.026 | - |
dc.identifier.wosid | WOS:000258357200011 | - |
dc.identifier.scopusid | 2-s2.0-48149099083 | - |
dc.author.google | Krishnan V. | - |
dc.author.google | Graham A. | - |
dc.author.google | Mazei-Robison M.S. | - |
dc.author.google | Lagace D.C. | - |
dc.author.google | Kim K.-S. | - |
dc.author.google | Birnbaum S. | - |
dc.author.google | Eisch A.J. | - |
dc.author.google | Han P.-L. | - |
dc.author.google | Storm D.R. | - |
dc.author.google | Zachariou V. | - |
dc.author.google | Nestler E.J. | - |
dc.contributor.scopusid | 한평림(7201947605) | - |
dc.date.modifydate | 20230901081001 | - |