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dc.contributor.author한평림-
dc.date.accessioned2016-12-06T02:12:27Z-
dc.date.available2016-12-06T02:12:27Z-
dc.date.issued2008-
dc.identifier.issn0006-3223-
dc.identifier.otherOAK-4997-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/233030-
dc.description.abstractBackground: Adenylyl cyclases (ACs) represent a diverse family of enzymes responsible for the generation of cyclic adenosine monophosphate (cAMP), a key intracellular second messenger. The Ca2+/calmodulin-stimulated AC1 and AC8 isoforms as well as the calcium-inhibited AC5 isoform are abundantly expressed within limbic regions of the central nervous system. This study examines the contribution of these AC isoforms to emotional behavior. Methods: Male and female AC1/8 double knockout mice (DKO) and AC5 knockout mice (AC5KO) were examined on a series of standard laboratory assays of emotionality. Mice were also assayed for hippocampal cell proliferation and for changes in brain-derived neurotrophic factor signaling in the nucleus accumbens, amygdala, and hippocampus, three forebrain structures involved in the regulation of mood and affect. Results: The AC5KO mice showed striking anxiolytic and antidepressant phenotypes on standard behavioral assays. In contrast, AC1/8 DKO mice were hypoactive, exhibited diminished sucrose preference, and displayed alterations in neurotrophic signaling, generally consistent with a prodepressant phenotype. Neither line of mice displayed alterations in hippocampal cell proliferation. Conclusions: These data illustrate the complex manner in which Ca2+/calmodulin-stimulated ACs contribute to emotional behavior. In addition, they support the possibility that a selective AC5 antagonist would be of therapeutic value against depression and anxiety disorders. © 2008 Society of Biological Psychiatry.-
dc.languageEnglish-
dc.titleCalcium-Sensitive Adenylyl Cyclases in Depression and Anxiety: Behavioral and Biochemical Consequences of Isoform Targeting-
dc.typeArticle-
dc.relation.issue4-
dc.relation.volume64-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage336-
dc.relation.lastpage343-
dc.relation.journaltitleBiological Psychiatry-
dc.identifier.doi10.1016/j.biopsych.2008.03.026-
dc.identifier.wosidWOS:000258357200011-
dc.identifier.scopusid2-s2.0-48149099083-
dc.author.googleKrishnan V.-
dc.author.googleGraham A.-
dc.author.googleMazei-Robison M.S.-
dc.author.googleLagace D.C.-
dc.author.googleKim K.-S.-
dc.author.googleBirnbaum S.-
dc.author.googleEisch A.J.-
dc.author.googleHan P.-L.-
dc.author.googleStorm D.R.-
dc.author.googleZachariou V.-
dc.author.googleNestler E.J.-
dc.contributor.scopusid한평림(7201947605)-
dc.date.modifydate20170601143155-
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