Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 정구용 | * |
dc.date.accessioned | 2016-12-06T02:12:23Z | - |
dc.date.available | 2016-12-06T02:12:23Z | - |
dc.date.issued | 2008 | * |
dc.identifier.issn | 0041-1345 | * |
dc.identifier.other | OAK-5062 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232997 | - |
dc.description.abstract | Objectives: α-Melanocyte stimulating hormone (α-MSH) may ameliorate renal ischemia-reperfusion (I/R) injury. Recent data suggest that melanocortin receptors may be related to the anti-inflammatory and immunomodulating action for α-MSH. We designed this experiment to determine the renal distribution of α-MSH receptors; melanocortin-1 receptor (MC-1R) and melanocortin-3 receptor (MC-3R). Methods: Sprague-Dawley male rats (n = 24) were randomly divided into 2 groups: the sham (n = 2) and the operation groups with warm ischemia (n = 12). Animals in the operation group were subjected to 40 minutes of warm renal ischemia. Western blotting analyses and immunohistochemistry were employed to determine expression of MC-1R and MC-3R. Results: Expression of MC-1R and MC-3R was decreased on 1 day after reperfusion. Immunohistochemical study confirmed the findings of Western blot analysis. Conclusions: The present study demonstrated novel renal expression of MC-1R and MC-3R, especially in the outer medulla, representative of the renal I/R injury. Our current study suggested that the mechanisms of action of α-MSH may significantly attenuate the renal I/R injury by specific kidney-targeted effects via MC-Receptors as well as by systemic cytokine effects. © 2008. | * |
dc.language | English | * |
dc.title | Change of Melanocortin Receptor Expression in Rat Kidney Ischemia-Reperfusion Injury | * |
dc.type | Article | * |
dc.relation.issue | 7 | * |
dc.relation.volume | 40 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 2142 | * |
dc.relation.lastpage | 2144 | * |
dc.relation.journaltitle | Transplantation Proceedings | * |
dc.identifier.doi | 10.1016/j.transproceed.2008.07.101 | * |
dc.identifier.wosid | WOS:000259333400015 | * |
dc.identifier.scopusid | 2-s2.0-51249100220 | * |
dc.author.google | Lee Y.S. | * |
dc.author.google | Park J.J. | * |
dc.author.google | Chung K.Y. | * |
dc.contributor.scopusid | 정구용(24773386100;55788924300) | * |
dc.date.modifydate | 20240118130923 | * |