View : 10 Download: 0

An open-label, multicenter, flexible dose study to evaluate the efficacy and safety of viagra ® (Sildenafil Citrate) in Korean men with erectile dysfunction and arterial hypertension who are taking antihypertensive agents

Title
An open-label, multicenter, flexible dose study to evaluate the efficacy and safety of viagra ® (Sildenafil Citrate) in Korean men with erectile dysfunction and arterial hypertension who are taking antihypertensive agents
Authors
Park H.J.Park N.C.Shim H.B.Park J.K.Lee S.W.Park K.Kim S.W.Moon K.H.Lee D.H.Yoon S.J.
Ewha Authors
이동현
SCOPUS Author ID
이동현scopus
Issue Date
2008
Journal Title
Journal of Sexual Medicine
ISSN
1743-6095JCR Link
Citation
vol. 5, no. 10, pp. 2405 - 2413
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Introduction. Erectile dysfunction (ED) is common among men taking antihypertensive agents to control blood pressure. Aim. We evaluated the efficacy and safety of sildenafil citrate in men with ED taking antihypertensive agents. Methods. A total of 198 male subjects, aged 20 years and older were enrolled. This study was conducted for 10 weeks as an open-label, multicenter and flexible dose trial with a 2-week screening period and an 8-week treatment phase. Main Outcome Measures. Subjects were asked to complete Event Log Worksheets, as well as the International Index of Erectile Function (IIEF) and the Global Efficacy Assessment Questions (GEAQ) questionnaires during the study period. Results. The average age among the 167 subjects who completed the study was 55.8 (31.7 to 77.1). The scores for questions 3 and 4 of IIEF improved from 2.3 and 1.8 at baseline to 3.7 and 3.4 at week 4 and 3.8 and 3.4 at week 8, respectively. There were 86.3% of the patients reported improved erectile function at week 8; 88.3% of the patients reported improved ability to achieve sexual intercourse at week 8. There were no significant differences observed in the responses to questions 3 and 4 of IIEF and GEAQ by the number of antihypertensive agents taken. The adverse events were facial flushing (20.1%), headache (11.7%), palpitation (5.0%), rhinitis (2.8%), URI (2.8%), dizziness (2.2%), dyspnea (2.2%), and nausea (1.7%). Conclusions. Sildenafil citrate is an effective treatment for ED; it is safe and well tolerated by patients with ED taking multiple antihypertensive agents for arterial hypertension. © 2008 International Society for Sexual Medicine.
DOI
10.1111/j.1743-6109.2008.00864.x
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE