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dc.contributor.author이승진-
dc.date.accessioned2016-11-30T02:11:33Z-
dc.date.available2016-11-30T02:11:33Z-
dc.date.issued2008-
dc.identifier.issn1065-6995-
dc.identifier.otherOAK-5178-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/232937-
dc.description.abstractPeroxisome proliferator-activated receptor γ (PPARγ) ligands inhibit cell proliferation and induce apoptosis in cancer cells. Here we wished to determine whether the PPARγ ligand induces apoptosis and cell cycle arrest of the MDA-MB-231 cell, an estrogen receptor α negative breast cancer cell line. The treatment of MDA-MB-231 cell with PPARγ ligands was shown to induce inhibition of cell growth in a dose-dependent manner as determined by MTT assay. Cell cycle analysis showed a G1 arrest in MDA-MB-231 cells exposed to troglitazone. An apoptotic effect by troglitazone demonstrated that apoptotic cells elevated by 2.5-fold from the control level at 10 μM, to 3.1-fold at 50 μM and to 3.5-fold at 75 μM. Moreover, troglitazone treatment, applied in a dose-dependent manner, caused a marked decrease in pRb, cyclin D1, cyclin D2, cyclin D3, Cdk2, Cdk4 and Cdk6 expression as well as a significant increase in p21 and p27 expression. These results indicate that troglitazone causes growth inhibition, G1 arrest and apoptotic death of MDA-MB-231 cells. © 2008 International Federation for Cell Biology.-
dc.languageEnglish-
dc.titleInduction of G1 phase arrest and apoptosis in MDA-MB-231 breast cancer cells by troglitazone, a synthetic peroxisome proliferator-activated receptor γ (PPARγ) ligand-
dc.typeArticle-
dc.relation.issue8-
dc.relation.volume32-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage906-
dc.relation.lastpage912-
dc.relation.journaltitleCell Biology International-
dc.identifier.doi10.1016/j.cellbi.2008.04.011-
dc.identifier.wosidWOS:000260671600006-
dc.identifier.scopusid2-s2.0-47349108152-
dc.author.googleYu H.-N.-
dc.author.googleLee Y.-R.-
dc.author.googleNoh E.-M.-
dc.author.googleLee K.-S.-
dc.author.googleKim J.-S.-
dc.author.googleSong E.-K.-
dc.author.googleHan M.-K.-
dc.author.googleLee Y.-C.-
dc.author.googleKwon K.-B.-
dc.author.googleLee S.-J.-
dc.author.googleYoun H.J.-
dc.author.googleJung S.H.-
dc.contributor.scopusid이승진(57196249292)-
dc.date.modifydate20230118105419-
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약학대학 > 약학과 > Journal papers
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