Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이승진 | - |
dc.date.accessioned | 2016-11-30T02:11:33Z | - |
dc.date.available | 2016-11-30T02:11:33Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1065-6995 | - |
dc.identifier.other | OAK-5178 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232937 | - |
dc.description.abstract | Peroxisome proliferator-activated receptor γ (PPARγ) ligands inhibit cell proliferation and induce apoptosis in cancer cells. Here we wished to determine whether the PPARγ ligand induces apoptosis and cell cycle arrest of the MDA-MB-231 cell, an estrogen receptor α negative breast cancer cell line. The treatment of MDA-MB-231 cell with PPARγ ligands was shown to induce inhibition of cell growth in a dose-dependent manner as determined by MTT assay. Cell cycle analysis showed a G1 arrest in MDA-MB-231 cells exposed to troglitazone. An apoptotic effect by troglitazone demonstrated that apoptotic cells elevated by 2.5-fold from the control level at 10 μM, to 3.1-fold at 50 μM and to 3.5-fold at 75 μM. Moreover, troglitazone treatment, applied in a dose-dependent manner, caused a marked decrease in pRb, cyclin D1, cyclin D2, cyclin D3, Cdk2, Cdk4 and Cdk6 expression as well as a significant increase in p21 and p27 expression. These results indicate that troglitazone causes growth inhibition, G1 arrest and apoptotic death of MDA-MB-231 cells. © 2008 International Federation for Cell Biology. | - |
dc.language | English | - |
dc.title | Induction of G1 phase arrest and apoptosis in MDA-MB-231 breast cancer cells by troglitazone, a synthetic peroxisome proliferator-activated receptor γ (PPARγ) ligand | - |
dc.type | Article | - |
dc.relation.issue | 8 | - |
dc.relation.volume | 32 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 906 | - |
dc.relation.lastpage | 912 | - |
dc.relation.journaltitle | Cell Biology International | - |
dc.identifier.doi | 10.1016/j.cellbi.2008.04.011 | - |
dc.identifier.wosid | WOS:000260671600006 | - |
dc.identifier.scopusid | 2-s2.0-47349108152 | - |
dc.author.google | Yu H.-N. | - |
dc.author.google | Lee Y.-R. | - |
dc.author.google | Noh E.-M. | - |
dc.author.google | Lee K.-S. | - |
dc.author.google | Kim J.-S. | - |
dc.author.google | Song E.-K. | - |
dc.author.google | Han M.-K. | - |
dc.author.google | Lee Y.-C. | - |
dc.author.google | Kwon K.-B. | - |
dc.author.google | Lee S.-J. | - |
dc.author.google | Youn H.J. | - |
dc.author.google | Jung S.H. | - |
dc.contributor.scopusid | 이승진(57196249292) | - |
dc.date.modifydate | 20230118105419 | - |