NL repository
menu
검색
Library
Browse
Communities & Collections
By Date
Authors
Titles
Subject
My Repository
My Account
Receive email updates
Edit Profile
DSpace at EWHA
의과대학
의학과
Journal papers
View : 635 Download: 0
GSTM1 polymorphism along with PM10 exposure contributes to the risk of preterm delivery
Title
GSTM1 polymorphism along with PM10 exposure contributes to the risk of preterm delivery
Authors
Suh Y.-J.
;
Ha E.-H.
;
Park H.
;
Kim Y.-J.
;
Kim H.
;
Hong Y.-C.
Ewha Authors
하은희
;
김영주
;
박혜숙
SCOPUS Author ID
하은희
; 김영주
; 박혜숙
Issue Date
2008
Journal Title
Mutation Research - Genetic Toxicology and Environmental Mutagenesis
ISSN
1383-5718
Citation
Mutation Research - Genetic Toxicology and Environmental Mutagenesis vol. 656, no. 41276, pp. 62 - 67
Indexed
SCI; SCIE; SCOPUS
Document Type
Article
Abstract
We investigated the association between the risk of preterm delivery and each metabolic gene of glutathione S-transferases mu 1 (GSTM1), theta 1 (GSTT1) and cytochrome P450IA1 (CYP1A1) along with exposure to particulate matter <10 μm (PM10). This study was assumed to identify gene-environment interaction that increases the risk of preterm delivery. A case-control study was carried out on 117 women with preterm deliveries and 118 women with term deliveries in Seoul, Korea. Logistic regression analyses were performed to explore the impact of each gene, PM10 exposure and their interaction on the risk of preterm birth. The risk of preterm birth was associated with the GSTM1 null genotype only. Exposure to high levels of PM10 (≥75th percentile) during the third trimester of pregnancy was associated with an increased risk of preterm birth when compared to low-level exposure to PM10 (<75th percentile). We found that exposure to high levels of PM10 during the third trimester in the presence of the GSTM1 null genotype is significantly associated with the risk of preterm delivery. This finding is biologically plausible and provides evidence for a gene-environment interaction that increases the risk of preterm birth. © 2008 Elsevier B.V. All rights reserved.
DOI
10.1016/j.mrgentox.2008.07.006
Appears in Collections:
의과대학
>
의학과
>
Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML
Show full item record
Find@EWHA
트윗하기
BROWSE
Communities & Collections
By Date
Authors
Titles
Subject