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Dexamethasone increases angiopoietin-1 and quiescent hematopoietic stem cells: A novel mechanism of dexamethasone-induced hematoprotection

Title
Dexamethasone increases angiopoietin-1 and quiescent hematopoietic stem cells: A novel mechanism of dexamethasone-induced hematoprotection
Authors
Kim H.Choi J.-Y.Lee J.M.Park Y.S.Suh H.Song H.-R.Jo S.A.Jo I.
Ewha Authors
조인호
SCOPUS Author ID
조인호scopus
Issue Date
2008
Journal Title
FEBS Letters
ISSN
0014-5793JCR Link
Citation
vol. 582, no. 23-24, pp. 3509 - 3514
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Angiopoietin-1 (Ang-1) is known to have hematoprotective effects by increasing the quiescence of hematopoietic stem cells. However, it remains to be determined if the upregulation of Ang-1 and the subsequent increase in the quiescence of hematopoietic stem cells are also involved in the dexamethasone (Dex)-mediated bone marrow protection. Here Western blotting and flow cytometric analyses demonstrate that Dex increases the levels of Ang-1 in mouse bone marrow and the quiescence of hematopoietic stem cells. Our data for the first time suggest that the increased quiescence of hematopoietic stem cells provides a novel mechanism of Dex-induced hematoprotection. © 2008 Federation of European Biochemical Societies.
DOI
10.1016/j.febslet.2008.09.021
Appears in Collections:
의과대학 > 의학과 > Journal papers
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