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Genetic variants in the HLA-G region are associated with Kawasaki disease

Title
Genetic variants in the HLA-G region are associated with Kawasaki disease
Authors
Kim J.-J.Hong S.-J.Hong Y.M.Kim S.Kang M.-J.Kim K.-J.Seo E.-J.Yoo H.-W.Cheong H.-S.Shin H.-D.Park I.-S.Lee J.-K.
Ewha Authors
홍영미
SCOPUS Author ID
홍영미scopus
Issue Date
2008
Journal Title
Human Immunology
ISSN
0198-8859JCR Link
Citation
vol. 69, no. 12, pp. 867 - 871
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Kawasaki disease is an acute, self-limited vasculitis of infants and children, manifest as fever and signs of mucocutaneous inflammation. Treatment with high-dose immunoglobulin reduces systemic inflammation and prevents coronary artery lesions in Kawasaki disease. In this study, we investigated the possible association of the major histocompatibililty complex (MHC) region for the susceptibility to Kawasaki disease using an MHC panel of 2360 single nucleotide polymorphism (SNP) markers. Analysis of data obtained from screening MHC-specific SNP chips with 48 case and 90 control subjects revealed five candidate loci with significance levels of uncorrected p < 0.01. However, only one candidate locus (HLA-G) was confirmed to have a significant association with Kawasaki disease (rs2523790, odds ratio [OR] = 3.00, 95% confidence interval [95% CI] = 1.14-7.91, uncorrected p = 0.0263) in the replication study using 44 new case subjects and the previous 90 controls. In the fine mapping of the HLA-G locus, in particular, a nonsynonymous SNP (C/A) of the HLA-G gene (rs12722477, Leu134Ile) was significantly associated with Kawasaki disease (OR = 3.23, 95% CI = 1.12-9.32). A subgroup analysis showed that this association was more apparent in patients with coronary artery aneurysms (OR = 4.02, 95% CI = 1.23-13.19). Therefore, our results indicate that HLA-G may play a crucial role for the susceptibility to Kawasaki disease. © 2008 American Society for Histocompatibility and Immunogenetics.
DOI
10.1016/j.humimm.2008.10.002
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의학전문대학원 > 의학과 > Journal papers
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