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Synthesis of fluoroneplanocin A.

Title
Synthesis of fluoroneplanocin A.
Authors
Jeong L.S.Tosh D.K.Choi W.J.Pal S.
Ewha Authors
정낙신최원준
Issue Date
2008
Journal Title
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.]
ISSN
1934-9289JCR Link
Citation
vol. Chapter 14
Indexed
SCOPUS scopus
Abstract
Fluoroneplanocin A, designed as a potent mechanism-based irreversible inhibitor of S-adenosylhomocysteine hydrolase (SAH), is synthesized from D-ribose via a key D-cyclopentenone intermediate. This intermediate is synthesized using a stereoselective Grignard reaction, a ring-closing metathesis (RCM) reaction, and oxidative rearrangement as key steps.
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약학대학 > 약학과 > Journal papers
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