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Synthesis and antitumor activity of 1-beta-4-selenoarabinofuranosyl cytosine (4'-seleno-ara-C).

Title
Synthesis and antitumor activity of 1-beta-4-selenoarabinofuranosyl cytosine (4'-seleno-ara-C).
Authors
Lee H.Tosh D.K.Choi W.J.Kim Y.M.Lee S.K.Jeong L.S.
Ewha Authors
정낙신이상국최원준
Issue Date
2008
Journal Title
Nucleic acids symposium series (2004)
ISSN
1746-8272JCR Link
Citation
no. 52, pp. 639 - 640
Indexed
SCOPUS scopus
Abstract
4-Seleno analogue of 1-beta-arabinofuranosyl cytosine (ara-C) was synthesized via 4'-selenouridine as a key intermediate, which was easily prepared from D-ribose. The arabino configuration was achieved by chemoselective ring opening of the 2,2'-anhydro-4'-selenouridine. The synthesized 4'-seleno-ara-C showed potent antitumor activity (IC(50) = 1.5 microM) against stomach cancer cells (SNU638).
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약학대학 > 약학과 > Journal papers
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