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Prolonged atrial refractoriness predicts the onset of atrial fibrillation: A 12-year follow-up study

Title
Prolonged atrial refractoriness predicts the onset of atrial fibrillation: A 12-year follow-up study
Authors
Lee J.M.Lee H.Janardhan A.H.Park J.Joung B.Pak H.-N.Lee M.-H.Kim S.S.Hwang H.J.
Ewha Authors
박준범
SCOPUS Author ID
박준범scopus
Issue Date
2016
Journal Title
Heart Rhythm
ISSN
1547-5271JCR Link
Citation
vol. 13, no. 8, pp. 1575 - 1580
Keywords
Atrial fibrillationAtrial refractorinessEffective refractory period
Publisher
Elsevier B.V.
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Background Tissue refractoriness to conduction is a crucial electrophysiological factor in determining susceptibility to fibrillation. The relationship between atrial refractoriness and future onset of atrial fibrillation (AF) has not been well studied. Objectives We investigated whether atrial effective refractory period (AERP) was associated with AF occurrence in a relatively healthy population. Methods A total of 1308 patients with no overt structural heart diseases and no evidence of congestive heart failure who underwent electrophysiology studies for paroxysmal supraventricular tachycardia from January 1986 to January 2011 were included in the study (626 male, mean age 44 ± 16 years). Results AERP increased with increasing age. Over a mean follow-up of 12 years, 51 of 1308 subjects (3.9%) developed AF. In univariate analysis, baseline AERP ≥280 ms (hazard ratio [HR] 2.54, 95% confidence interval [CI] 1.27–5.07, P = .008) was strongly associated with new-onset AF. In multivariate Cox regression analysis, age (adjusted HR 1.40 per 10 years, 95% CI 1.15–1.70, P = .001) and AERP ≥280 ms (adjusted HR 2.08, 95% CI 1.03–4.21, P = .041) were associated with new-onset AF. Kaplan-Meier AF-free survival curves demonstrated that subjects with an AERP of ≥280 ms had significantly lower AF-free survival compared those with AERP of <280 ms. Conclusions AERP increases with age and AERP of ≥280 ms was predictive of patients at significantly increased future risk of developing AF. © 2016 Heart Rhythm Society
DOI
10.1016/j.hrthm.2016.03.037
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의학전문대학원 > 의학과 > Journal papers
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