Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 현동훈 | * |
dc.date.accessioned | 2016-11-18T02:11:46Z | - |
dc.date.available | 2016-11-18T02:11:46Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 0253-6269 | * |
dc.identifier.issn | 1976-3786 | * |
dc.identifier.other | OAK-19515 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232744 | - |
dc.description.abstract | Lipid-soluble ginseng extracts (LSGE) is known to inhibit many types of cancer cells through arresting cell cycle and inducing apoptosis. Usually, normal cells are can also be damaged by anti-tumor reagents. The plasma membrane redox system (PMRS) is enhanced to compensate mitochondrial dysfunction and impaired energy metabolism. NADH-quinone oxidoreductase 1 (NQO1), a plasma membrane redox enzyme, is known to be induced by panaxytriol, one of components of lipid-soluble ginseng extracts (LSGE). The objective of this study was determine the mechanisms of NQO1 involved in neuroprotection in response to cytotoxicity induced by LSGE. Exposure of control SH-SY5Y cells to LSGE resulted in dramatic loss of cell viability in a dose-dependent manner. The loss of cell viability was significantly recovered in cells transfected with NQO1. LSGE-induced cell death occurred through apoptosis such as cell shrinkage, chromatin condensation and cleavage of poly (ADP-ribose) polymerase. These apoptotic features were significantly attenuated by overexpression of NQO1. Levels of oxidative/nitrative damage were highly elevated by LSGE in a dose-dependent manner. However, these elevated levels were greatly reduced by overexpression of NQO1. In addition, overexpression of NQO1 attenuated the decrease in mitochondrial complex I activity caused by LSGE. Taken together, these findings suggest that overexpressed NQO1 can protect cells against LSGE-induced cytotoxicity through lowering oxidative/nitrative damage and delaying apoptosis, supporting that stimulation of NQO1 activity could be a therapeutic targets in neurodegeration. | * |
dc.language | English | * |
dc.publisher | PHARMACEUTICAL SOC KOREA | * |
dc.subject | Lipid-soluble ginseng extracts | * |
dc.subject | NQO1 | * |
dc.subject | PMRS | * |
dc.subject | Oxidative damage | * |
dc.subject | Apoptosis | * |
dc.title | Cytotoxicity of lipid-soluble ginseng extracts is attenuated by plasma membrane redox enzyme NQO1 through maintaining redox homeostasis and delaying apoptosis in human neuroblastoma cells | * |
dc.type | Review | * |
dc.relation.issue | 10 | * |
dc.relation.volume | 39 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 1339 | * |
dc.relation.lastpage | 1348 | * |
dc.relation.journaltitle | ARCHIVES OF PHARMACAL RESEARCH | * |
dc.identifier.doi | 10.1007/s12272-016-0817-6 | * |
dc.identifier.wosid | WOS:000386351000001 | * |
dc.identifier.scopusid | 2-s2.0-84990872104 | * |
dc.author.google | Kim, Hwa-Kyung | * |
dc.author.google | Son, Tae Gen | * |
dc.author.google | Jo, Dong-Gyu | * |
dc.author.google | Kim, Dong Chung | * |
dc.author.google | Hyun, Dong-Hoon | * |
dc.contributor.scopusid | 현동훈(7005049041) | * |
dc.date.modifydate | 20240123112641 | * |