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Weight Change Is a Characteristic Non-Motor Symptom in Drug-Naive Parkinson's Disease Patients with Non-Tremor Dominant Subtype: A Nation-Wide Observational Study

Title
Weight Change Is a Characteristic Non-Motor Symptom in Drug-Naive Parkinson's Disease Patients with Non-Tremor Dominant Subtype: A Nation-Wide Observational Study
Authors
Mun, Jun KyuYoun, JinyoungCho, Jin WhanOh, Eung-SeokKim, Ji SunPark, SuyeonJang, WooyoungPark, Jin SeKoh, Seong-BeomLee, Jae HyeokPark, Hee KyungKim, Han-JoonJeon, Beom S.Shin, Hae-WonChoi, Sun-AhKim, Sang JinChoi, Seong-MinPark, Ji-YunKim, Ji YoungChung, Sun JuLee, Chong SikAhn, Tae-BeomKim, Won ChanKim, Hyun SookCheon, Sang MyungKim, Jae WooKim, Hee-TaeLee, Jee-YoungKim, Eun-JooKim, Jong-MinLee, Kwang SooKim, Joong-SeokKim, Min-JeongBaik, Jong SamPark, Ki-JongKim, Hee JinPark, Mee YoungKang, Ji HoonSong, Sook KunKim, Yong DukYun, Ji YoungLee, Ho-WonSong, In-UkSohn, Young H.Lee, Phil HyuPark, Jeong-HoOh, Hyung GeunPark, Kun WooKwon, Do-Young
Ewha Authors
윤지영
SCOPUS Author ID
윤지영scopusscopus
Issue Date
2016
Journal Title
PLOS ONE
ISSN
1932-6203JCR Link
Citation
vol. 11, no. 9
Publisher
PUBLIC LIBRARY SCIENCE
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Despite the clinical impact of non-motor symptoms (NMS) in Parkinson's disease (PD), the characteristic NMS in relation to the motor subtypes of PD is not well elucidated. In this study, we enrolled drug-naive PD patients and compared NMS between PD subtypes. We enrolled 136 drug-naive, early PD patients and 50 normal controls. All the enrolled PD patients were divided into tremor dominant (TD) and non-tremor dominant (NTD) subtypes. The Non-Motor Symptom Scale and scales for each NMS were completed. We compared NMS and the relationship of NMS with quality of life between normal controls and PD patients, and between the PD subtypes. Comparing with normal controls, PD patients complained of more NMS, especially mood/cognitive symptoms, gastrointestinal symptoms, unexplained pain, weight change, and change in taste or smell. Between the PD subtypes, the NTD subtype showed higher total NMS scale score and sub-score about weight change. Weight change was the characteristic NMS related to NTD subtype even after controlled other variables with logistic regression analysis. Even from the early stage, PD patients suffer from various NMS regardless of dopaminergic medication. Among the various NMS, weight change is the characteristic NMS associated with NTD subtype in PD patients.
DOI
10.1371/journal.pone.0162254
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의료원 > 의료원 > Journal papers
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