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Self-assembled mirror DNA nanostructures for tumor-specific delivery of anticancer drugs

Title
Self-assembled mirror DNA nanostructures for tumor-specific delivery of anticancer drugs
Authors
Kim, Kyoung-RanKim, Hyo YoungLee, Yong-DeokHa, Jong SeongKang, Ji HeeJeong, HansaemBang, DuheeKo, Young TagKim, SehoonLee, HyukjinAhn, Dae-Ro
Ewha Authors
이혁진
SCOPUS Author ID
이혁진scopus
Issue Date
2016
Journal Title
JOURNAL OF CONTROLLED RELEASE
ISSN
0168-3659JCR Link1873-4995JCR Link
Citation
vol. 243, pp. 121 - 131
Keywords
DNA nanostructureMirror DNATumor-targeted deliveryDoxorubicin
Publisher
ELSEVIER SCIENCE BV
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Nanoparticle delivery systems have been extensively investigated for targeted delivery of anticancer drugs over the past decades. However, it is still a great challenge to overcome the drawbacks of conventional nanoparticle systems such as liposomes and micelles. Various novel nanomaterials consist of natural polymers are proposed to enhance the therapeutic efficacy of anticancer drugs. Among them, deoxyribonucleic acid (DNA) has received much attention as an emerging material for preparation of self-assembled nanostructures with precise control of size and shape for tailored uses. In this study, self-assembled mirror DNA tetrahedron nanostructures is developed for tumor-specific delivery of anticancer drugs. L-DNA, a mirror form of natural D-DNA, is utilized for resolving a poor serum stability of natural D-DNA. The mirror DNA nanostructures show identical thermodynamic properties to that of natural D-DNA, while possessing far enhanced serum stability. This unique characteristic results in a significant effect on the pharmacokinetics and biodistribution of DNA nanostructures. It is demonstrated that the mirror DNA nanostructures can deliver anticancer drugs selectively to tumors with enhanced cellular and tissue penetration. Furthermore, the mirror DNA nanostructures show greater anticancer effects as compared to that of conventional PEGylated liposomes. Our new approach provides an alternative strategy for tumor-specific delivery of anticancer drugs and highlights the promising potential of the mirror DNA nanostructures as a novel drug delivery platform. (C) 2016 Elsevier B.V. All rights reserved.
DOI
10.1016/j.jconrel.2016.10.015
Appears in Collections:
약학대학 > 약학과 > Journal papers
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