Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 심현보 | * |
dc.date.accessioned | 2016-11-18T02:11:40Z | - |
dc.date.available | 2016-11-18T02:11:40Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 2058-5276 | * |
dc.identifier.other | OAK-19577 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232708 | - |
dc.description.abstract | The N-terminal truncated form of a protein synthesis enzyme, tryptophanyl-tRNA synthetase (mini-WRS), is secreted as an angiostatic ligand. However, the secretion and function of the full-length WRS (FL-WRS) remain unknown. Here, we report that the FL-WRS, but not mini-WRS, is rapidly secreted upon pathogen infection to prime innate immunity. Blood levels of FL-WRS were increased in sepsis patients, but not in those with sterile inflammation. FL-WRS was secreted from monocytes and directly bound to macrophages via a toll-like receptor 4 (TLR4)-myeloid differentiation factor 2 (MD2) complex to induce phagocytosis and chemokine production. Administration of FL-WRS into Salmonella typhimurium-infected mice reduced the levels of bacteria and improved mouse survival, whereas its titration with the specific antibody aggravated the infection. The N-terminal 154-amino-acid eukaryote-specific peptide of WRS was sufficient to recapitulate FL-WRS activity and its interaction mode with TLR4-MD2 is now suggested. Based on these results, secretion of FL-WRS appears to work as a primary defence system against infection, acting before full activation of innate immunity. | * |
dc.language | English | * |
dc.publisher | NATURE PUBLISHING GROUP | * |
dc.title | Secreted tryptophanyl-tRNA synthetase as a primary defence system against infection | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 2 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | NATURE MICROBIOLOGY | * |
dc.identifier.doi | 10.1038/nmicrobiol.2016.191 | * |
dc.identifier.wosid | WOS:000396366300011 | * |
dc.identifier.scopusid | 2-s2.0-84992362225 | * |
dc.author.google | Ahn, Young Ha | * |
dc.author.google | Park, Sunyoung | * |
dc.author.google | Choi, Jeong June | * |
dc.author.google | Park, Bo-Kyung | * |
dc.author.google | Rhee, Kyung Hee | * |
dc.author.google | Kang, Eunjoo | * |
dc.author.google | Ahn, Soyeon | * |
dc.author.google | Lee, Chul-Ho | * |
dc.author.google | Lee, Jong Soo | * |
dc.author.google | Inn, Kyung-Soo | * |
dc.author.google | Cho, Mi-La | * |
dc.author.google | Park, Sung-Hwan | * |
dc.author.google | Park, Kyunghee | * |
dc.author.google | Park, Hye Jung | * |
dc.author.google | Lee, Jae-Hyun | * |
dc.author.google | Park, Jung-Won | * |
dc.author.google | Kwon, Nam Hoon | * |
dc.author.google | Shim, Hyunbo | * |
dc.author.google | Han, Byung Woo | * |
dc.author.google | Kim, Pilhan | * |
dc.author.google | Lee, Joo-Youn | * |
dc.author.google | Jeon, Youngho | * |
dc.author.google | Huh, Jin Won | * |
dc.author.google | Jin, Mirim | * |
dc.author.google | Kim, Sunghoon | * |
dc.contributor.scopusid | 심현보(26635827900) | * |
dc.date.modifydate | 20240123110611 | * |