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Ajoene restored behavioral patterns and liver glutathione level in morphine treated C57BL6 mice

Title
Ajoene restored behavioral patterns and liver glutathione level in morphine treated C57BL6 mice
Authors
Yun, JaesukOliynyk, SergiyLee, YeonjuKim, JieunYun, KyunghwaJeon, RaokRyu, Jae-HaOh, Seikwan
Ewha Authors
오세관
SCOPUS Author ID
오세관scopus
Issue Date
2017
Journal Title
ARCHIVES OF PHARMACAL RESEARCH
ISSN
0253-6269JCR Link1976-3786JCR Link
Citation
vol. 40, no. 1, pp. 106 - 111
Keywords
AjoeneMorphineHepatic glutathioneBehavioral patternsMice
Publisher
PHARMACEUTICAL SOC KOREA
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Oxidative stress exacerbates drug dependence induced by administration of opiate analgesics such as morphine-induced tolerance and physical dependence associated with the reduction in hepatic glutathione (GSH) level. Ajoene obtained from garlic (Allium sativum L.) has been reported for anti-tumorigenic, anti-oxidative and neuroprotective properties, however, little is known about its effect on morphine-induced dependence. Therefore, this study aimed at the effect of ajoene on physical and/or psychological dependence and liver GSH content in morphine-treated mice. Conditioned place preference (CPP) test and measurement of morphine withdrawal syndrome were performed in C57BL6 mice for behavioral experiments. Thereafter, mice were sacrificed for measurement of serum and liver GSH levels. Ajoene restored CPP and naloxone-precipitated jumping behavior in mice exposed to morphine. Moreover, the reduced level of liver GSH content in morphine treated mice was back to normal after ajoene administration. Taken together, ajoene improved behavioral patterns in mice exposed to morphine suggesting its potential therapeutic benefit against morphine-induced dependence.
DOI
10.1007/s12272-016-0773-1
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의학전문대학원 > 의학과 > Journal papers
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