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Prenatal exposure to perfluorinated compounds affects thyroid hormone levels in newborn girls

Title
Prenatal exposure to perfluorinated compounds affects thyroid hormone levels in newborn girls
Authors
Shah-Kulkarni, SurabhiKim, Byung-MiHong, Yun-ChulKim, Hae SoonKwon, Eun JinPark, HyesookKim, Young JuHa, Eun-Hee
Ewha Authors
하은희김영주김혜순박혜숙
SCOPUS Author ID
하은희scopus; 김영주scopus; 김혜순scopus; 박혜숙scopus
Issue Date
2016
Journal Title
ENVIRONMENT INTERNATIONAL
ISSN
0160-4120JCR Link1873-6750JCR Link
Citation
vol. 94, pp. 607 - 613
Keywords
Perfluorinated compoundsThyroid hormonesGirls
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Perfluorinated compounds (PFCs) are ubiquitous in the environment and have been detected in humans and wildlife. Exposure to PFCs has decreased in the United States recently, while exposure to PFCs continues in Asian countries, which represents a public health concern. Various mechanisms by which PFCs affect fetal growth have been proposed, such as activation of peroxisome proliferators, disruption of thyroid hormones and changes in lipid metabolism. However, the overall evidence for an association with thyroid hormones is not strong. Therefore, we examined the effect of various prenatal PFC5 on cord blood thyroid hormones: triiodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH) levels, and explored the endocrine disrupting effect of these PFCs on thyroid hormone levels in children according to gender. Two hundred and seventy-nine study participants were selected from among the enrolled participants in the Ewha Birth & Growth Retrospective Cohort, a retrospective birth cohort study conducted at Ewha Womans University Hospital, Seoul, Korea between 2006 and 2010. A generalized linear model was constructed to explore the association of PFCs and thyroid hormones. Further, an analysis stratified by gender was conducted. Our study shows that cord blood perfluoro n-pentanoic acid (PFPeA) was positively associated with cord blood T4 (p = 0.01) level. Gender-specific analysis showed that prenatal PFCs: PFPeA and Perfluorohexane sulfonic acid (PFHxS) exposure significantly increased T4 (p < 0.01) and T3 (p = 0.03), respectively, while perfluorononanoic acid (PFNA) decreased TSH (p = 0.04) concentration in newborn girls. Thus, prenatal PFC exposure may disrupt thyroid hormone homeostasis. Thyroid hormones play a crucial role in fetal development and may have gender specific action. Hence, these results are of utmost importance in high-risk groups, such as pregnant women and children. (C) 2016 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.envint.2016.06.024
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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