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Long-Term Recurrence Rates of Peptic Ulcers without Helicobacter pylori

Title
Long-Term Recurrence Rates of Peptic Ulcers without Helicobacter pylori
Authors
Seo, Jae HyunHong, Su JinKim, Jie-HyunKim, Byung-WookJee, Sam RyongChung, Woo ChulShim, Ki-NamBaik, Gwang HoKim, Sung SooKim, Sang GyunKim, Jin Il
Ewha Authors
심기남
SCOPUS Author ID
심기남scopus
Issue Date
2016
Journal Title
GUT AND LIVER
ISSN
1976-2283JCR Link2005-1212JCR Link
Citation
vol. 10, no. 5, pp. 719 - 725
Keywords
Natural courseHelicobacter negativePeptic ulcer disease
Publisher
EDITORIAL OFFICE GUT & LIVER
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Background/Aims: The purpose of this study is to investigate the recurrence rate of peptic ulcer disease (PUD) over a long follow-up period with PUD patients without Helicobacter pylori. Methods: We retrospectively reviewed patients diagnosed with PUD on endoscopy and divided them into two groups: a H. pylori-negative group (HP-negative group), and a group of patients with untreated H. pylori (HP noneradicated group). We compared the recurrence rates of PUD in these two groups and analyzed the factors that affected ulcer recurrence. Results: Total of nine hospitals in Korea participated, and a total of 1,761 patients were retrospectively reviewed. The HP-negative group included 553 patients, and the HP noneradicated group included 372 patients. The 5-year cumulative probabilities of PUD recurrence were 36.4% in the HP-negative group and 43.8% in the HP noneradicated group (p=0.113). The factors that were found to affect recurrence in the HP-negative group were elder, male, and comorbid chronic kidney disease. Conclusions: The 5-year cumulative probability of PUD recurrence without H. pylori infection after a long-term follow-up was 36.4% and the factors that affected recurrence were elder, male, and comorbid chronic kidney disease.
DOI
10.5009/gnl15262
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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