View : 106 Download: 0

Association between Aortic Atheroma and Cerebral Small Vessel Disease in Patients with Ischemic Stroke

Title
Association between Aortic Atheroma and Cerebral Small Vessel Disease in Patients with Ischemic Stroke
Authors
Song, Tae-JinKim, Young DaeYoo, JoonsangKim, JinkwonChang, Hyuk-JaeHong, Geu RuShim, Chi YoungSong, DongbeomHeo, Ji HoeNam, Hyo Suk
Ewha Authors
송태진
SCOPUS Author ID
송태진scopus
Issue Date
2016
Journal Title
JOURNAL OF STROKE
ISSN
2287-6391JCR Link2287-6405JCR Link
Citation
vol. 18, no. 3, pp. 312 - 320
Keywords
Aortic atheromaCerebral small vessel diseasesWhite matter hyperintensity
Publisher
KOREAN STROKE SOC
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Background and Purpose Cerebral small vessel disease (SVDs) are related with large artery atherosclerosis. However, the association between aortic atheroma (AA) and cerebral small vessel disease has rarely been reported. This study evaluated the relationship between presence and burden of AAs and those of SVDs in patients with acute ischemic stroke. Methods We included 737 consecutive patients who underwent transesophageal echocardiography (TEE) and brain magnetic resonance imaging (MRI) for evaluation of acute stroke. AA subtypes were classified as complex aortic plaque (CAP) and simple aortic plaque (SAP). Presence and burden of SVDs including cerebral microbleeds (CMBs), white matter hyperintensities (WMHs), perivascular spaces (PVSs), asymptomatic lacunar infarctions (ALls), and total SVD score, were investigated. Results AA was found by TEE in 360 (48.8%) patients including 11.6% with CAP and 37.2% with SAP. One or more types of SVDs was found in 269 (36.4%) patients. In multivariable analysis, presence of CMBs (odds ratio [OR] 4.68), high-grade WMHs (OR 3.13), high-grade PVSs (OR 3.35), and ALls (OR 4.24) were frequent in patients with AA than those without AA. Each 1-point increase in total SVD score increased the odds of presence of CAP (OR 1.94, 95% confidence interval (CI) 1.44-1.85) and SAP (OR 1.54, 95% CI 1.35-1.75). Conclusions In this study, patients with AA frequently had cerebral SVDs. Larger burden of AA was associated with advanced cerebral SVDs. Our findings give an additional information for positive relationship with systemic atherosclerosis and coexisting cerebral SVDs in acute ischemic stroke patients.
DOI
10.5853/jos.2016.00171
Appears in Collections:
의료원 > 의료원 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE