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The Role of Cerebrovascular Disease in Amyloid Deposition

Title
The Role of Cerebrovascular Disease in Amyloid Deposition
Authors
Noh, YoungSeo, Sang WonJeon, SeunLee, Jong MinKim, Jae SeungLee, Jae-HongKim, Jung-HyunKim, Geon HaYe, Byoung SeokCho, HannaKim, Hee JinYoon, Cindy W.Choe, Yearn SeongLee, Kyung-HanWeiner, Michael W.Na, Duk L.
Ewha Authors
김건하
SCOPUS Author ID
김건하scopus
Issue Date
2016
Journal Title
JOURNAL OF ALZHEIMERS DISEASE
ISSN
1387-2877JCR Link1875-8908JCR Link
Citation
vol. 54, no. 3, pp. 1015 - 1026
Keywords
Alzheimer's diseasecerebrovascular diseasemagnetic resonance imagingpositron emission tomographyvascular dementia
Publisher
IOS PRESS
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Background: Some patients clinically diagnosed with subcortical vascular cognitive impairment (SVCI) have co-morbidity with AD pathology. Objective: We investigated topographical differences in amyloid burden between SVCI and Alzheimer's disease type cognitive impairment (ADCI) using [C-11] Pittsburgh compound B (PiB) positron emission tomography (PET). The purpose of this study was to investigate the role of cerebrovascular disease (CVD) in amyloid deposition. Methods: We recruited 44 patients with SVCI and 44 patients with ADCI (amnestic mild cognitive impairment or Alzheimer's disease) with absent or minimal white matter hyperintensities, all with PiB-positive PET scans [PiB+]. As controls, we included 13 participants with normal cognition and PiB-negative scans. We divided the SVCI and ADCI patients into three groups according to global PiB retention ratio of SVCI, and then compared the tertiles in terms of the distribution of PiB retention using statistical parametric mapping analyses. Lobar to global PiB retention ratio and asymmetry indices were also compared between SVCI and ADCI groups Results: Compared to PiB+ ADCI patients, PiB+ SVCI patients exhibited: 1) increased left-right asymmetry, and increased anterior-posterior difference; and 2) increased PiB retention in the parietal cortex, the occipital cortex and the precuneus-posterior cingulate cortex. In contrast, ADCI patients showed increased PiB retention in the striatum. When stratified by level of PiB retention, each group showed different characteristics. Conclusion: Our results showed that the distribution of amyloid deposition differed between patients with PiB+ SVCI and ADCI. These suggest that CVD contribute to and alter the known progression pattern in amyloid deposition in Alzheimer's disease.
DOI
10.3233/JAD-150832
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연구기관 > 뇌융합과학연구원 > Journal papers
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