Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이수영 | * |
dc.date.accessioned | 2016-11-15T02:11:29Z | - |
dc.date.available | 2016-11-15T02:11:29Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 1976-6696 | * |
dc.identifier.issn | 1976-670X | * |
dc.identifier.other | OAK-19536 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232641 | - |
dc.description.abstract | Toll-like receptors (TLRs) play a critical role in the innate immune response against pathogens. Each TLR recognizes specific pathogen-associated molecular patterns, after which they activate the adaptor protein MyD88 or TRIF-assembled signaling complex to produce immune mediators, including inflammatory cytokines and type I IFNs. Although the activation of TLR is important for host defense, its uncontrolled activation can damage the host. During the past decade, numerous studies have demonstrated that GSK3 beta is a key regulator of inflammatory cytokine production in MyD88-mediated TLR signaling via TLR2 and TLR4. Recently, GSK3 beta has also been implicated in the TRIF-dependent signaling pathway via TLR3. In this review, we describe current advances on the regulatory role of GSK3 beta in immune responses associated with various TLRs. A better understanding of the role of GSK3 beta. in TLR signaling might lead to more effective anti-inflammatory interventions. | * |
dc.language | English | * |
dc.publisher | KOREAN SOCIETY BIOCHEMISTRY & | * |
dc.publisher | MOLECULAR BIOLOGY | * |
dc.subject | Glycogen synthase kinase 3 beta (GSK3 beta) | * |
dc.subject | Inflammatory cytokines | * |
dc.subject | Toll-like receptor (TLR) | * |
dc.subject | Type I interferons (IFNs) | * |
dc.title | Glycogen synthase kinase 3 beta in Toll-like receptor signaling | * |
dc.type | Review | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 49 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 305 | * |
dc.relation.lastpage | 310 | * |
dc.relation.journaltitle | BMB REPORTS | * |
dc.identifier.doi | 10.5483/BMBRep.2016.49.6.059 | * |
dc.identifier.wosid | WOS:000384755400002 | * |
dc.identifier.scopusid | 2-s2.0-84991338153 | * |
dc.author.google | Ko, Ryeojin | * |
dc.author.google | Lee, Soo Young | * |
dc.contributor.scopusid | 이수영(53980218900;7409697278) | * |
dc.date.modifydate | 20240415140424 | * |